ArticleGenes & development2011
Nitric oxide directly regulates gene expression during Drosophila development: need some gas to drive into metamorphosis?
Article in Genes & development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Dietary L-arginine accelerates pupation and promotes high protein levels but induces oxidative stress and reduces fecundity and life span in Drosophila melanogaster.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Article
- Article
- The Drosophila IMD pathway in the activation of the humoral immune response.Developmental and comparative immunology · 2014Review
- Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity.The EMBO journal · 2013Article
- Developmental checkpoints and feedback circuits time insect maturation.Current topics in developmental biology · 2013Review
- Ecdysone control of developmental transitions: lessons from Drosophila research.Annual review of entomology · 2013Review
- Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Nitric oxide (NO) is an important second messenger involved in numerous biological processes, but how it regulates gene expression is not well understood. In this issue of Genes & Development, Cáceres and colleagues (pp. 1476-1485) report a critical requirement of NO as a direct regulator of gene expression through its binding to a heme-containing nuclear receptor in Drosophila. This may be an anciently evolved mechanism to coordinate behavior and metabolism during animal development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.