ArticleBioorganic & medicinal chemistry2012
Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP.
Article in Bioorganic & medicinal chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Leaf Apoplast of Field-Grown Potato Analyzed by Quantitative Proteomics and Activity-Based Protein Profiling.International journal of molecular sciences · 2021Article
- Effects of Chlorpyrifos on Serine Hydrolase Activities, Lipid Mediators, and Immune Responses in Lungs of Neonatal and Adult Mice.Chemical research in toxicology · 2021Article
- Fulvic acid increases forage legume growth inducing preferential up-regulation of nodulation and signalling-related genes.Journal of experimental botany · 2020Article
- Activity-based protein profiling of rice (Oryza sativa L.) bran serine hydrolases.Scientific reports · 2020Article
- Targeted Covalent Inhibition of Telomerase.ACS chemical biology · 2020Article
- Design and synthesis of a novel photoaffinity probe for labelling EGF receptor tyrosine kinases.Journal of enzyme inhibition and medicinal chemistry · 2017Article
- Novel Vein Patterns in Arabidopsis Induced by Small Molecules.Plant physiology · 2016Article
- Target identification strategies in plant chemical biology.Frontiers in plant science · 2014Review
- Article
- Mining the Active Proteome of Arabidopsis thaliana.Frontiers in plant science · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Organophosphate and -phosphonates and their thio derivatives are often used in agroindustry as herbicides and insecticides, but their potential off-targets in the plant are poorly investigated. Here, we use competitive activity-based protein profiling (ABPP) of serine hydrolases (SHs) to detect targets of these agrochemicals and other compounds in Arabidopsis thaliana. Using broad-range and specific probes, and by overexpression of various SHs in planta, we are able to confirm eight SH-compound interactions, including selective inhibition of carboxylesterase CXE12, prolyloligopeptidase, methylesterase MES2 and tripeptidyl peptidase TPP2. These observations can be used for the design of novel probes and selective inhibitors and may help to assess physiological effects of agrochemicals on crop plants.
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Registered trials
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