ArticleNeurobiology of aging2012
Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction.
Article in Neurobiology of aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 76 citations in OpenAlex.
- Epigenetics in development, disease, and therapy: from mechanisms to clinical interventions.Science China. Life sciences · 2026Review
- Epigenetic Regulation of Aging and its Rejuvenation.MedComm · 2025Review
- Molecular and Cellular Foundations of Aging of the Brain: Anti-aging Strategies in Alzheimer's Disease.Cellular and molecular neurobiology · 2024Review
- How can we modulate aging through nutrition and physical exercise? An epigenetic approach.Aging · 2023Review
- DNA Methylation Signature of Aging: Potential Impact on the Pathogenesis of Parkinson's Disease.Journal of Parkinson's disease · 2023Review
- Sex-specific variations in global DNA methylation levels with age: a population-based exploratory study from North India.Frontiers in genetics · 2023Article
- The epigenetic aging, obesity, and lifestyle.Frontiers in cell and developmental biology · 2022Review
- Article
- Epigenetics in Alzheimer's Disease.Frontiers in aging neuroscience · 2022Review
- Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion.Mechanisms of ageing and development · 2021Article
- Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging.Frontiers in physiology · 2021Review
- Review
- Targeting epigenetic mechanisms for chronic visceral pain: A valid approach for the development of novel therapeutics.Neurogastroenterology and motility · 2019Review
- Impaired fear extinction in serotonin transporter knockout rats is associated with increased 5-hydroxymethylcytosine in the amygdala.CNS neuroscience & therapeutics · 2018Article
- DNA methylation of TOMM40-APOE-APOC2 in Alzheimer's disease.Journal of human genetics · 2018Article
- Revisiting the genomic hypomethylation hypothesis of aging.Annals of the New York Academy of Sciences · 2018Article
- Epigenetic Modifications of theOxidative medicine and cellular longevity · 2018Article
- Age-related Disturbances in DNA (hydroxy)methylation in APP/PS1 Mice.Translational neuroscience · 2018Article
- Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease.Molecular and cellular neurosciences · 2018Article
- NicotinamideInternational journal of tryptophan research : IJTR · 2017Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
Aberrant DNA methylation patterns have been linked to molecular and cellular alterations in the aging brain. Caloric restriction (CR) and upregulation of antioxidants have been proposed as interventions to prevent or delay age-related brain pathology. Previously, we have shown in large cohorts of aging mice, that age-related increases in DNA methyltransferase 3a (Dnmt3a) immunoreactivity in the mouse hippocampus were attenuated by CR, but not by overexpression of superoxide dismutase 1 (SOD1). Here, we investigated age-related alterations of 5-methylcytidine (5-mC), a marker of DNA methylation levels, in a hippocampal subregion-specific manner. Examination of 5-mC immunoreactivity in 12- and 24-month-old wild type (WT) mice on control diet, mice overexpressing SOD1 on control diet, wild type mice on CR, and SOD1 mice on CR, indicated an age-related increase in 5-mC immunoreactivity in the hippocampal dentate gyrus, CA3, and CA1-2 regions, which was prevented by CR but not by SOD1 overexpression. Moreover, positive correlations between 5-mC and Dnmt3a immunoreactivity were observed in the CA3 and CA1-2. These findings suggest a crucial role for DNA methylation in hippocampal aging and in the mediation of the beneficial effects of CR on aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.