ArticleManual therapy2011
Heightened pain sensitivity in individuals with signs and symptoms of carpal tunnel syndrome and the relationship to clinical outcomes following a manual therapy intervention.
Article in Manual therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00929123 (Mechanisms of Neural Mobilization in the Treatment of Chronic Pain), which is not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mechanisms of Neural Mobilization in the Treatment of Chronic Pain
Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Preoperative Physiotherapy Effects on Hand Function and Quality of Life in Carpal Tunnel Syndrome: 3 - & 6 - month randomized controlled trial.The Journal of manual & manipulative therapy · 2025Trial
- The comparative effects of spinal and peripheral thrust manipulation and exercise on pain sensitivity and the relation to clinical outcome: a mechanistic trial using a shoulder pain model.The Journal of orthopaedic and sports physical therapy · 2015Trial
- Trial
- Evoked pain analgesia in chronic pelvic pain patients using respiratory-gated auricular vagal afferent nerve stimulation.Pain medicine (Malden, Mass.) · 2012Trial
- Central Sensitization in Patients with Chronic Pain Secondary to Carpal Tunnel Syndrome and Determinants.Journal of pain research · 2023Article
- Carpal tunnel surgery dampens thalamocortical and normalizes corticocortical functional connectivity.Brain communications · 2022Article
- Facilitatory and inhibitory pain mechanisms are altered in patients with carpal tunnel syndrome.PloS one · 2017Article
- Experimental pain responses support peripheral and central sensitization in patients with unilateral shoulder pain.The Clinical journal of pain · 2014Article
- Entrapment of the saphenous nerve at the adductor canal affecting the infrapatellar branch - a report on two cases.The Journal of the Canadian Chiropractic Association · 2013Article
- Relationship between electrodiagnostic severity and neuropathic pain assessed by the LANSS pain scale in carpal tunnel syndrome.Neuropsychiatric disease and treatment · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Neurophysiological responses related to lessening of pain sensitivity are a suggested mechanism of manual therapy. Prior studies have observed generalized lower pain thresholds associated with carpal tunnel syndrome (CTS) in comparison to healthy controls. The present study sought to determine whether similar findings were present in suprathreshold measures and measures specific to central integration of pain (temporal summation and after sensations). Additionally, we wished to determine whether measures of pain sensitivity were related to clinical outcomes in participants with signs and symptoms of CTS receiving a manual therapy intervention. Individuals with signs and symptoms of CTS reported greater pain sensitivity to suprathreshold measures of mechanical pain, temporal summation, and after sensation in comparison to healthy controls. Immediate lessening of mechanical pain sensitivity and after sensations in response to a manual therapy intervention and 3-week attenuation of temporal summation following a 3-week course of manual therapy were associated with 3-week changes in clinical pain intensity in participants with signs and symptoms of CTS. These findings suggest heightened pain sensitivity across several parameters may be associated with CTS. Furthermore, changes in mechanical pain, after sensation, and temporal summation may be related to improvements in clinical outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.