ReviewCurrent opinion in genetics & development2011
Defects in translational regulation contributing to human cognitive and behavioral disease.
Review in Current opinion in genetics & development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- The fragile X proteins' enigma: to be or not to be nucleolar.Frontiers in cell and developmental biology · 2024Article
- Autoimmune RNA dysregulation and seizures: therapeutic prospects in neuropsychiatric lupus.Life science alliance · 2022Article
- Upregulation of eIF4E, but not other translation initiation factors, in dendritic spines during memory formation.The Journal of comparative neurology · 2021Article
- centrocortin RNA localization to centrosomes is regulated by FMRP and facilitates error-free mitosis.The Journal of cell biology · 2020Article
- Effect of Fabomotizole on Brain Gene Expression in MR Rats in the Open Field Test.Doklady. Biochemistry and biophysics · 2019Article
- Changes in neuronal immunofluorescence in the C- versus N-terminal domains of hnRNP H following D1 dopamine receptor activation.Neuroscience letters · 2018Article
- Developmental lead (Pb)-induced deficits in hippocampal protein translation at the synapses are ameliorated by ascorbate supplementation.Neuropsychiatric disease and treatment · 2018Article
- Regulatory BC1 RNA in cognitive control.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Accumulation of Polyribosomes in Dendritic Spine Heads, But Not Bases and Necks, during Memory Consolidation Depends on Cap-Dependent Translation Initiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Crystal structure of a dimerization domain of human Caprin-1: insights into the assembly of an evolutionarily conserved ribonucleoprotein complex consisting of Caprin-1, FMRP and G3BP1.Acta crystallographica. Section D, Structural biology · 2016Article
- Integrative analysis of RNA, translation, and protein levels reveals distinct regulatory variation across humans.Genome research · 2015Article
- Phelan-McDermid Syndrome and SHANK3: Implications for Treatment.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- Emerging roles of tRNA in adaptive translation, signalling dynamics and disease.Nature reviews. Genetics · 2015Review
- Article
- Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent translational control.The Journal of cell biology · 2014Article
- Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.The EMBO journal · 2014Article
- iPSC-derived forebrain neurons from FXS individuals show defects in initial neurite outgrowth.Stem cells and development · 2014Article
- Interactions of noncanonical motifs with hnRNP A2 promote activity-dependent RNA transport in neurons.The Journal of cell biology · 2014Article
- Convergence of genes and cellular pathways dysregulated in autism spectrum disorders.American journal of human genetics · 2014Article
- Increasing our understanding of human cognition through the study of Fragile X Syndrome.Developmental neurobiology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Recent data suggest that the levels of many synaptic proteins may be tightly controlled by the opposing processes of new translation and protein turnover in neurons. Alterations in this balance or in the levels of such dosage-sensitive proteins that result in altered stoichiometry of protein complexes at developing and remodeling synapses may underlie several human cognitive diseases including Fragile X Syndrome, autism spectrum disorders, Angelman syndrome and non-syndromic mental retardation. While a significant amount is known about the transduction of membrane signals to the translational apparatus through kinase cascades acting on general translation factors, much less is understood about how such signals may influence the activity of mRNA-specific regulators, their mechanisms of action and the specific sets of mRNAs they regulate. New approaches to the unbiased in vivo identification of maps of binding sites for these proteins on mRNA is expected to greatly increase our understanding of this crucial level of regulation in neuronal development and function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.