Evidence map›Paper›PMID 21764215›Full record

Trial reportPain2011

Ten sessions of adjunctive left prefrontal rTMS significantly reduces fibromyalgia pain: a randomized, controlled pilot study.

Baron E Short, Jeffrey J Borckardt, Berry S Anderson, Heather Frohman, William Beam, Scott T Reeves, Mark S George

4 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pain, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00523302 nacompletednot on this map

A Pilot Study of Transcranial Magnetic Stimulation (TMS) Effects on Pain and Depression in Patients With Fibromyalgia

TypeinterventionalSponsorMedical University of South CarolinaRan2007 to 2009Enrolled20ConditionsMajor Depression, FibromyalgiaArmsActive TMS, Sham TMS
NCT02120690 phase1 / phase2unknown statusnot on this mapstarted 2014, after this paper: background citation

Trigeminal Nerve Stimulation (TNS) as a Complementary Strategy in the Treatment of Fibromyalgia, Open Label Study

TypeinterventionalSponsorSanta Casa Medical SchoolRan2014 to 2015Enrolled40ConditionsFibromyalgiaArmsTrigeminal nerve stimulation
NCT02969707 nacompletednot on this mapstarted 2017, after this paper: background citation

Use of Repetitive Transcranial Magnetic Stimulation to Augment Hypnotic Analgesia

TypeinterventionalSponsorStanford UniversityRan2017 to 2019Enrolled101ConditionsFibromyalgiaArmsMagPro TMS system (MagVenture, Denmark), Hypnosis
NCT04864080 narecruitingnot on this mapstarted 2022, after this paper: background citation

Transdiagnostic Cognitive Biomarkers

TypeinterventionalSponsorUniversity of MinnesotaRan2022 to 2027Enrolled45ConditionsPain, DepressionArmsComputer game/task, Health surveys online
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 146 citations in OpenAlex.

  1. Non-invasive brain stimulation techniques for chronic pain.The Cochrane database of systematic reviews · 2018
    Pooled it
  2. Non-invasive brain stimulation techniques for chronic pain.The Cochrane database of systematic reviews · 2018
    Pooled it
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  12. Adjunctive D-cycloserine to intermittent theta-burst transcranial magnetic stimulation in fibromyalgia: a randomized placebo-controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Baron E ShortBrain Stimulation Laboratory, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President St., PO Box 250861, Charleston, SC 29425, USA Department of Anesthesia & Perioperative Medicine, Medical University of South Carolina, MSC 912, Rm 301, 167 Ashley Ave., Charleston, SC 29425, USA College of Nursing, Medical University of South Carolina, PO Box 250160, 99 Jonathan Lucas St., Charleston, SC 29425, USA Ralph H. Johnson VA Medical Center, 109 Bee Street, Charleston, SC 29401, USA.
Jeffrey J Borckardt
Berry S Anderson
Heather Frohman
William Beam
Scott T Reeves
Mark S George
Medical University of South Carolina · USRalph H. Johnson VA Medical Center · US

Funding

Sphingosine Kinase in Systemic Sclerosis (Scleroderma)P60AR049459 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SILVER, RICHARD M. · 2003 to 2007
$6.0M
NIAMS NIH HHS P60 AR049459
6 · The paper itself

Abstract

Transcranial magnetic stimulation (TMS) of the prefrontal cortex can cause changes in acute pain perception. Several weeks of daily left prefrontal TMS has been shown to treat depression. We recruited 20 patients with fibromyalgia, defined by American College of Rheumatology criteria, and randomized them to receive 4000 pulses at 10 Hz TMS (n=10), or sham TMS (n=10) treatment for 10 sessions over 2 weeks along with their standard medications, which were fixed and stable for at least 4 weeks before starting sessions. Subjects recorded daily pain, mood, and activity. Blinded raters assessed pain, mood, functional status, and tender points weekly with the Brief Pain Inventory, Hamilton Depression Rating Scale, and Fibromyalgia Impact Questionnaire. No statistically significant differences between groups were observed. Patients who received active TMS had a mean 29% (statistically significant) reduction in pain symptoms in comparison to their baseline pain. Sham TMS participants had a 4% nonsignificant change in daily pain from their baseline pain. At 2 weeks after treatment, there was a significant improvement in depression symptoms in the active group compared to baseline. Pain reduction preceded antidepressant effects. TMS was well tolerated, with few side effects. Further studies that address study limitations are needed to determine whether daily prefrontal TMS may be an effective, durable, and clinically useful treatment for fibromyalgia symptoms.

Indexed as

AdultAgedChronic PainDepressionFemaleFibromyalgiaHumansMaleMedical RecordsMiddle AgedPilot ProjectsPrefrontal CortexTranscranial Magnetic Stimulation

Identifiers

PMID21764215
PMCPMC3199360
OpenAlexW2000273088

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.