Evidence map›Paper›PMID 21763962›Full record

ReviewHematology/oncology clinics of North America2011

New insights into the biology of renal cell carcinoma.

Lianjie Li, William G Kaelin

Abstract readReview
In one paragraph

Review in Hematology/oncology clinics of North America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  10. Review
  11. The immunology of renal cell carcinoma.Nature reviews. Nephrology · 2020
    Review
  12. What morphology can teach us about renal cell carcinoma clonal evolution.Kidney cancer journal : official journal of the Kidney Cancer Association · 2020
    Article
  13. The mProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  14. Leveraging insights into cancer metabolism-a symposium report.Annals of the New York Academy of Sciences · 2020
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lianjie LiHoward Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA.
William G Kaelin

Funding

Treating the P13-Kinase/AKTP50CA101942 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Wanling Xie · 2003 to 2026
$53.4M
The von Hippel-Lindau Tumor Suppressor Protein:Roles in Cancer and Oxygen SensingR01CA068490 · NCI · DANA-FARBER CANCER INSTITUTE · PI KAELIN, WILLIAM G. · 1996 to 2015
$4.8M
Howard Hughes Medical InstituteNCI NIH HHS P50 CA101942NCI NIH HHS R01 CA068490
6 · The paper itself

Abstract

Ninety percent or more of kidney cancers are believed to be of epithelial cell origin, and are referred to as renal cell carcinoma (RCC), which are further subdivided based on histology into clear-cell RCC (75%), papillary RCC (15%), chromophobe tumor (5%), and oncocytoma (5%). Some genes confer an increased risk of these various histologic RCC subtypes. In practice, there is some overlap among the histologic subtypes, and there are some shared molecular features among these tumor types. This review focuses primarily on the most common form of RCC, clear-cell renal carcinoma, noting some recent advances in the other histologic subtypes.

Indexed as

Adenoma, OxyphilicCarcinoma, Renal CellGene Expression Regulation, NeoplasticHumansHypoxia-Inducible Factor 1, alpha SubunitKidney NeoplasmsVascular Endothelial Growth Factor AVon Hippel-Lindau Tumor Suppressor ProteinHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitVascular Endothelial Growth Factor AVHL protein, humanVon Hippel-Lindau Tumor Suppressor Protein

Identifiers

PMID21763962
PMCPMC3161447

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.