Evidence map›Paper›PMID 21763253›Full record

ReviewBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation2011

NCI, NHLBI first international consensus conference on late effects after pediatric hematopoietic cell transplantation: etiology and pathogenesis of late effects after HCT performed in childhood--methodologic challenges.

Smita Bhatia, Stella M Davies, K Scott Baker, Michael A Pulsipher, John A Hansen

Open access · hybridAbstract readReview
In one paragraph

Review in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
  2. Haematopoietic stem cell transplantation for children and young people: is there a role for prehabilitation? A scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Cardiovascular Risk Factors in Survivors of Childhood Hematopoietic Cell Transplantation Treated with Total Body Irradiation: A Longitudinal Analysis.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2017
    Article
  9. Review
  10. Article
  11. Physical Activity, Fitness, and Cardiometabolic Risk Factors in Adult Survivors of Childhood Cancer with a History of Hematopoietic Cell Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2015
    Article
  12. Challenges and opportunities for international cooperative studies in pediatric hematopoeitic cell transplantation: priorities of the Westhafen Intercontinental Group.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2013
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Smita BhatiaDepartment of Population Sciences, City of Hope, Duarte, California 91010-3000, USA. sbhatia@coh.org
Stella M Davies
K Scott Baker
Michael A Pulsipher
John A Hansen
Fred Hutch Cancer Center · USChildren's Medical Center · USCincinnati Children's Hospital Medical Center · USCity of Hope · US

Funding

Vaccine-Induced Immunity to CMVP01CA030206 · NCI · CITY OF HOPE NATIONAL MEDICAL CENTER · PI FORMAN, STEPHEN J · 1985 to 2010
$31.8M
TRANSPLANTATION IMMUNOLOGYP01AI033484 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HANSEN, JOHN ANDREW · 1992 to 2013
$13.1M
Whole Genome Association Analysis of Hematopoietic Cell Transplant (HCT) OutcomeR01HL105914 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MARTIN, PAUL J · 2011 to 2019
$9.8M
Role of Genetic Susceptibility in Therapy-related Subsequent MalignanciesR01CA139633 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BHATIA, SMITA · 2010 to 2014
$3.1M
Pediatric Blood and Marrow Transplant ConsortiumU01HL069254 · NHLBI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI PULSIPHER, MICHAEL A · 2001 to 2010
$2.0M
Biomarker Discovery in Chronic Graft-vs-Host DiseaseR01HL094260 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HANSEN, JOHN ANDREW · 2008 to 2011
$1.8M
BONE MARROW TRANSPLANT (BMT) SURVIVORS STUDYR01CA078938 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI BHATIA, SMITA · 2000 to 2003
$1.6M
Late Effects after Pediatric HSCT: State of the Science, Future DirectionsR13CA159788 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI BAKER, KEVIN S, PULSIPHER, MICHAEL A · 2011 to 2011
$13k
NCI NIH HHS 1R13CA159788-01NCI NIH HHS P01 CA030206NCI NIH HHS P01 CA 30206NCI NIH HHS R01 CA078938NCI NIH HHS R01 CA139633NCI NIH HHS R13 CA159788NHLBI NIH HHS R01 HL094260NHLBI NIH HHS R01 HL105914NHLBI NIH HHS U01 HL069254NHLBI NIH HHS U01HL069254NIAID NIH HHS P01 AI033484NIAID NIH HHS P01 AI33484NIAID NIH HHS R01 AI094260NIAID NIH HHS R01 AI105914
6 · The paper itself

Abstract

Hematopoietic cell transplantation (HCT) is now a curative option for certain categories of patients with hematologic malignancies and other life-threatening illnesses. Technical and supportive care has resulted in survival rates that exceed 70% for those who survive the first 2 years after HCT. However, long-term survivors carry a high burden of morbidity, including endocrinopathies, musculoskeletal disorders, cardiopulmonary compromise, and subsequent malignancies. Understanding the etiologic pathways that lead to specific post-HCT morbidities is critical to developing targeted prevention and intervention strategies. Understanding the molecular underpinnings associated with graft-versus-host disease (GVHD), organ toxicity, relapse, opportunistic infection, and other long-term complications now recognized as health care concerns will have significant impact on translational research aimed at developing novel targeted therapies for controlling chronic GVHD, facilitating tolerance and immune reconstitution, reducing risk of relapse and secondary malignancies, minimizing chronic metabolic disorders, and improving quality of life. However, several methodological challenges exist in achieving these goals; these issues are discussed in detail in this paper.

Indexed as

AdolescentChildChild, PreschoolChronic DiseaseConsensus Statements as TopicEndocrine System DiseasesFemaleGraft vs Host DiseaseHeart DiseasesHematologic NeoplasmsHematopoietic Stem Cell TransplantationHumansInfantLung DiseasesMaleMetabolic Diseases

Identifiers

PMID21763253
PMCPMC3177028
OpenAlexW2017290338

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.