Evidence map›Paper›PMID 21763124›Full record

ReviewCurrent opinion in neurobiology2011

New methods for localizing and manipulating neuronal dynamics in behaving animals.

Michale S Fee, Michael A Long

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Many parameter sets in a multicompartment model oscillator are robust to temperature perturbations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Article
  5. Intracellular recording in behaving animals.Current opinion in neurobiology · 2012
    Review
  6. Article
  7. Two distinct modes of forebrain circuit dynamics underlie temporal patterning in the vocalizations of young songbirds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michale S FeeMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. fee@MIT.EDU
Michael A Long

Funding

Synaptic and circuit mechanisms of learned vocal productionR01NS075044 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MICHAEL A LONG · 2011 to 2026
$5.7M
Performance Error Signals in Basal Ganglia-Forebrain Circuits of the SongbirdR01MH067105 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FEE, MICHALE S · 2005 to 2014
$3.6M
Cellular and Synaptic Rules Enabling Vocal CommunicationR00DC009280 · NIDCD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LONG, MICHAEL A · 2010 to 2012
$725k
NIDCD NIH HHS DC009280NIDCD NIH HHS R00 DC009280NIMH NIH HHS MH067105NIMH NIH HHS R01 MH067105NINDS NIH HHS R01 NS075044
6 · The paper itself

Abstract

Where are the 'prime movers' that control behavior? Which circuits in the brain control the order in which individual motor gestures of a learned behavior are generated, and the speed at which they progress? Here we describe two techniques recently applied to localizing and characterizing the circuitry underlying the generation of vocal sequences in the songbird. The first utilizes small, localized, temperature changes in the brain to perturb the speed of neural dynamics. The second utilizes intracellular manipulation of membrane potential in the freely behaving animal to perturb the dynamics within a single neuron. Both of these techniques are broadly applicable in behaving animals to test hypotheses about the biophysical and circuit dynamics that allow neural circuits to march from one state to the next.

Indexed as

Body TemperatureAnimalsBrainMembrane PotentialsModels, NeurologicalNerve NetNeuronsNonlinear DynamicsSongbirdsVocalization, Animal

Identifiers

PMID21763124
PMCPMC3223334

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.