ArticleThe Journal of allergy and clinical immunology2011
Allergic sensitization can be induced via multiple physiologic routes in an adjuvant-dependent manner.
Article in The Journal of allergy and clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 91 citations in OpenAlex.
- Intestinal uptake regulates T cell responses to dietary antigens.bioRxiv : the preprint server for biology · 2026Article
- The Role of the Indoor Exposome in Food Allergy Development.Current allergy and asthma reports · 2026Review
- Demonstration of Gliadin Penetration into the Epidermis by Tape Stripping as Prerequisite for Percutaneous Sensitisation in Wheat Allergy.International journal of molecular sciences · 2026Article
- Dendritic Cells: at the Crossroads between Oral Tolerance and Food Allergy.Current allergy and asthma reports · 2025Review
- Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice.Science (New York, N.Y.) · 2025Article
- Identification of antigen-presenting cell-T cell interactions driving immune responses to food.Science (New York, N.Y.) · 2025Article
- A user's guide to designing efficient and safe mucosal vaccines: Challenges & potentials.Oxford open immunology · 2025Review
- Dendritic cells in food allergy, treatment, and tolerance.The Journal of allergy and clinical immunology · 2024Review
- A single priming event prevents oral tolerance to peanut.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023Article
- Environmental Exposure to Foods as a Risk Factor for Food Allergy.Current allergy and asthma reports · 2023Review
- Epicutaneous Sensitization and Food Allergy: Preventive Strategies Targeting Skin Barrier Repair-Facts and Challenges.Nutrients · 2023Review
- Enterosorbents in complex therapy of food allergies: a focus on digestive disorders and systemic toxicity in children.Frontiers in immunology · 2023Review
- Immunomodulatory effect of marine lipids on food allergy.Frontiers in nutrition · 2023Review
- Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens.Science translational medicine · 2022Article
- Assessment of the Route of Exposure to Ovalbumin and Cow's Milk Proteins on the Induction of IgE Responses in BALB/c Mice.Biology · 2022Article
- Thymic stromal lymphopoietin, skin barrier dysfunction, and the atopic march.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021Review
- Goat's milk allergy in a family following household sensitization to goat's milk soap.Asia Pacific allergy · 2021Article
- The Role of Type 2 Innate Lymphoid Cells in Allergic Diseases.Frontiers in immunology · 2021Review
- Statement onEFSA journal. European Food Safety Authority · 2021Article
- The External Exposome and Food Allergy.Current allergy and asthma reports · 2020Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOral exposure to food allergens may be limited in infancy, and the initial site of antigen exposure likely plays an important role in food allergy induction.
objectiveTo examine the impact of different routes of exposure by using milk allergens, with and without adjuvant, on sensitization.
methodsC3H/HeJ mice were repeatedly exposed to the milk allergen α-lactalbumin (ALA), with or without cholera toxin (CT). Sensitization routes used were intragastric, cutaneous, intranasal, and sublingual. Anaphylaxis severity was assessed by symptoms and body temperature in response to oral challenge. Antigen-specific serum antibodies were measured by ELISA. The mechanism of adjuvant activity of cutaneous CT was also determined.
resultsSensitization to ALA as measured by allergen-specific IgE occurred by all routes of sensitization and was maximal in response to cutaneous exposure. Sensitization was dependent on CT and did not occur to antigen alone by any route. Mucosal, but not cutaneous, exposure resulted in a robust allergen-specific IgA response. Anaphylaxis occurred in all sensitized groups when orally challenged with ALA. Topical CT induced migration of langerin(neg) dermal dendritic cells to the lymph node, resulting in enhanced proliferation and T(H)2 cytokine production from responder T cells.
conclusionsSensitization can occur via all physiologic routes when adjuvant is present. The skin is a potent and likely important physiologic route of sensitization whereby adjuvant induces an efflux of antigen-bearing dermal dendritic cells to the lymph node that generate a proallergic T(H)2 response.
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