ArticleBMC gastroenterology2011
Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation.
Article in BMC gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 70 citations in OpenAlex.
- Allergic proctocolitis: Evaluation and management.Journal of food allergy · 2025Review
- Review
- Allergic Proctocolitis: Literature Review and Proposal of a Diagnostic-Therapeutic Algorithm.Life (Basel, Switzerland) · 2023Review
- Non-IgE mediated food allergies in breastfed children: A clinical challenge.Allergologie select · 2022Review
- Food protein-induced allergic proctocolitis in infants: Literature review and proposal of a management protocol.The World Allergy Organization journal · 2020Review
- Review
- Fecal microbiota transplantation induces remission of infantile allergic colitis through gut microbiota re-establishment.World journal of gastroenterology · 2017Article
- Non-IgE-mediated Adverse Food Reactions.Current allergy and asthma reports · 2017Review
- Hematochezia caused by eosinophilic proctocolitis in a newborn before oral feeding: a case report.Journal of medical case reports · 2017Article
- Allergic enteritis in children.Przeglad gastroenterologiczny · 2017Review
- Diagnosis of Food Allergy.Pediatric clinics of North America · 2015Review
- Food allergen sensitization in young children with typical signs and symptoms of immediate-type food allergies: a comparison between monosensitized and polysensitized children.Korean journal of pediatrics · 2015Article
- Food Protein-Induced Enterocolitis Syndrome, Allergic Proctocolitis, and Enteropathy.Current allergy and asthma reports · 2015Review
- Characteristics of allergic colitis in breast-fed infants in the absence of cow's milk allergy.World journal of gastroenterology · 2013Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAllergic proctocolitis (APC) in exclusively breast-fed infants is caused by food proteins, deriving from maternal diet, transferred through lactation. In most cases a maternal cow milk-free diet leads to a prompt resolution of rectal bleeding, while in some patients a multiple food allergy can occur. The aim of this study was to assess whether the atopy patch test (APT) could be helpful to identify this subgroup of patients requiring to discontinue breast-feeding due to polisensitization. Additionally, we assessed the efficacy of an amino acid-based formula (AAF) when multiple food allergy is suspected. amino acid-based formula
methodsWe have prospectively enrolled 14 exclusively breast-fed infants with APC refractory to maternal allergen avoidance. The diagnosis was confirmed by endoscopy with biopsies. Skin prick tests and serum specific IgE for common foods, together with APTs for common foods plus breast milk, were performed. After a 1 month therapy of an AAF all patients underwent a follow-up rectosigmoidoscopy.
resultsPrick tests and serum specific IgE were negative. APTs were positive in 100% infants, with a multiple positivity in 50%. Sensitization was found for breast milk in 100%, cow's milk (50%), soy (28%), egg (21%), rice (14%), wheat (7%). Follow-up rectosigmoidoscopy confirmed the remission of APC in all infants.
conclusionsThese data suggest that APT might become a useful tool to identify subgroups of infants with multiple gastrointestinal food allergy involving a delayed immunogenic mechanism, with the aim to avoid unnecessary maternal dietary restrictions before discontinuing breast-feeding.
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