Trial reportAlcoholism, clinical and experimental research2011
Bidirectional interactions between acute psychosocial stress and acute intravenous alcohol in healthy men.
Trial report in Alcoholism, clinical and experimental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Effect of alcohol on blood pressure.The Cochrane database of systematic reviews · 2020Pooled it
- Alcohol craving under stress in healthy young men: A randomized laboratory study.Alcohol, clinical & experimental research · 2026Trial
- Individual stress reactivity predicts alcohol craving and alcohol consumption in alcohol use disorder in experimental and real-life settings.Translational psychiatry · 2025Trial
- Predator odor (TMT) exposure potentiates interoceptive sensitivity to alcohol and increases GABAergic gene expression in the anterior insular cortex and nucleus accumbens in male rats.Alcohol (Fayetteville, N.Y.) · 2022Article
- Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways.Psychopharmacology · 2022Review
- Interoception and alcohol: Mechanisms, networks, and implications.Neuropharmacology · 2021Review
- Prevalence and factors associated with alcohol consumption among persons with diabetes in Kampala, Uganda: a cross sectional study.BMC public health · 2021Article
- Discriminative Stimulus Effects and Metabolism of Ethanol in Rhesus Monkeys.Alcoholism, clinical and experimental research · 2019Article
- Gender-Specific Association between Alcohol Consumption and Stress Perception, Depressed Mood, and Suicidal Ideation: The 2010-2015 KNHANES.Psychiatry investigation · 2019Article
- Binge drinking in adolescence predicts an atypical cortisol stress response in young adulthood.Psychoneuroendocrinology · 2019Article
- Sex differences in stress-related alcohol use.Neurobiology of stress · 2019Review
- Drug-induced stress responses and addiction risk and relapse.Neurobiology of stress · 2019Review
- Conditioning cortisol in humans: design and pilot study of a randomized controlled trial.Pilot and feasibility studies · 2019Article
- Intra- and Interindividual Variability in the Behavioral, Affective, and Perceptual Effects of Alcohol Consumption in a Social Context.Alcoholism, clinical and experimental research · 2018Article
- Convergent Neuronal Plasticity and Metaplasticity Mechanisms of Stress, Nicotine, and Alcohol.Annual review of pharmacology and toxicology · 2018Review
- Pharmacological challenge studies with acute psychosocial stress.Psychoneuroendocrinology · 2017Review
- Naltrexone moderates the relationship between cue-induced craving and subjective response to methamphetamine in individuals with methamphetamine use disorder.Psychopharmacology · 2017Article
- Opposing effects of alcohol on the immune system.Progress in neuro-psychopharmacology & biological psychiatry · 2016Review
- Depression, Anxiety and Symptoms of Stress among Hong Kong Nurses: A Cross-sectional Study.International journal of environmental research and public health · 2015Article
- Activation of mGluR2/3 following stress hormone exposure restores sensitivity to alcohol in rats.Alcohol (Fayetteville, N.Y.) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe biological mechanisms by which acute stress increases alcohol consumption are unclear. One potential mechanism is that stress acts by altering the pharmacological and subjective effects of alcohol. Acute stress produces a cascade of physiological and psychological effects, each with a distinctive time course. In this study, we investigated whether different phases of response to an acute stress alter the subjective effects of intravenous alcohol, by administering the drug at 2 different times after the stress.
methodsHealthy men (n = 25) participated in 2 sessions: 1 with the Trier Social Stress Test and the other with a nonstressful control task, each followed by infusions of intravenous alcohol (targeting 40 mg% in 5 minutes) and placebo. One group of participants received alcohol within 1 minute of completing the tasks (Alc0, n = 11), followed by placebo 30 minutes later. In the other group (Alc30, n = 14), the order of alcohol and placebo infusions was reversed. Subjective effects (i.e., anxiety, stimulation, want more) and physiological measures (heart rate, blood pressure, salivary cortisol) were measured before and at repeated intervals after the tasks and infusions.
resultsStress did not change the subjective effects of alcohol in either group. However, when individual differences in alcohol responses were considered, stress differentially altered the stimulant-like and sedative effects of alcohol. Among individuals who exhibited predominantly stimulant responses to alcohol in the nonstressful condition, stress decreased the stimulant-like effects of alcohol and "wanting more." By contrast, among participants who did not report stimulation after alcohol in the control session, stress decreased the sedative effects and increased "want more." In addition, alcohol administered immediately after the Trier Social Stress Test dampened cortisol responses yet prolonged negative subjective responses to the stress.
conclusionsThese findings demonstrate that there are bidirectional relationships between alcohol and stress. Alcohol influences responses to stress, and stress changes reactions to alcohol, depending on an individual's pattern of response to alcohol. This study highlights the fact that stress-alcohol interactions vary among individual drinkers, suggesting that the effects of stress on motivation to drink alcohol may also differ between individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.