ArticleAnalytical chemistry2011
Reversible cation response with a protein-modified nanopipette.
Article in Analytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Detection of Biological Molecules Using Nanopore Sensing Techniques.Biomedicines · 2023Review
- Nanoneedle-Based Materials for Intracellular Studies.Advances in experimental medicine and biology · 2021Article
- Nanopore detection of metal ions: Current status and future directions.Small methods · 2020Article
- Article
- Review
- Review
- Bioinspired integrated nanosystems based on solid-state nanopores: "Chemical science · 2017Article
- Smartphone Operated Signal Transduction by Ion Nanogating (STING) Amplifier for Nanopore Sensors: Design and Analytical Application.ACS sensors · 2016Article
- Single Cell "Glucose Nanosensor" Verifies Elevated Glucose Levels in Individual Cancer Cells.Nano letters · 2016Article
- Conductivity-based detection techniques in nanofluidic devices.The Analyst · 2015Review
- Single-cell intracellular nano-pH probes.RSC advances · 2015Article
- Article
- Nanopipette exploring nanoworld.Nano convergence · 2014Review
- Article
- Carbohydrate-actuated nanofluidic diode: switchable current rectification in a nanopipette.Nanoscale · 2013Article
- Article
- Copper Sensing with a Prion Protein Modified Nanopipette.RSC advances · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The calcium ion response of a quartz nanopipette was enhanced by immobilization of calmodulin to the nanopore surface. Binding to the analyte is rapidly reversible in neutral buffer and requires no change in media or conditions to regenerate the receptor. The signal remained reproducible over numerous measurements. The modified nanopipette was used to measure binding affinity to calcium ions, with a K(d) of 6.3 ± 0.8 × 10(-5) M. This affinity is in good agreement with reported values of the solution-state protein. The behavior of such reversible nanopore-based sensors can be used to study proteins in a confined environment and may lead to new devices for continuous monitoring.
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Registered trials
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