ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2011
Quantitative three-dimensional imaging of live avian embryonic morphogenesis via micro-computed tomography.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- 3D vascular quantitation with application to computational modeling: a pre-clinical light sheet microscopy, high resolution ultrasound, nano-computed tomography comparison study.bioRxiv : the preprint server for biology · 2026Article
- An optimized CT-dense agent perfusion and micro-CT imaging protocol for chick embryo developmental stages.BMC biomedical engineering · 2024Article
- Monitoring egg fertility, embryonic morbidity, and mortality in an oviparous elasmobranch using ultrasonography.Frontiers in veterinary science · 2024Article
- Dynamic 3D morphology of chick embryos and allantois depicted nondestructively by 3.0T clinical magnetic resonance imaging.Poultry science · 2023Article
- Toxicological Analysis by Assessment of Vascularization and Cell Viability Using the Chicken's Chorioallantoic Membrane (CAM Assay).Methods in molecular biology (Clifton, N.J.) · 2023Article
- Review
- Micro-CT-Based Bone Microarchitecture Analysis of the Murine Skull.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo.Frontiers in physiology · 2022Article
- Review
- Computational Modeling of Blood Flow Hemodynamics for Biomechanical Investigation of Cardiac Development and Disease.Journal of cardiovascular development and disease · 2021Review
- The Chorioallantoic Membrane Assay in Nanotoxicological Research-An Alternative forNanomaterials (Basel, Switzerland) · 2020Review
- Monitoring of tumor growth and vascularization with repetitive ultrasonography in the chicken chorioallantoic-membrane-assay.Scientific reports · 2020Article
- Bone Marrow Adipose Tissue Quantification by Imaging.Current osteoporosis reports · 2019Review
- Embryonic Chicken (Comparative medicine · 2019Review
- Comparative analysis of metallic nanoparticles as exogenous soft tissue contrast for live in vivo micro-computed tomography imaging of avian embryonic morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Imaging the zebrafish dentition: from traditional approaches to emerging technologies.Zebrafish · 2015Review
- Micro/nano-computed tomography technology for quantitative dynamic, multi-scale imaging of morphogenesis.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Investigating developmental cardiovascular biomechanics and the origins of congenital heart defects.Frontiers in physiology · 2014Review
- Quantitative analysis of microscopic X-ray computed tomography imaging: Japanese quail embryonic soft tissues with iodine staining.Journal of anatomy · 2013Article
- Translational paradigms in scientific and clinical imaging of cardiac development.Birth defects research. Part C, Embryo today : reviews · 2013Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Many clinically relevant congenital malformations arise during mid to late embryonic stages. This period is challenging to image quantitatively in live embryos, necessitating the use of multiple specimens with increased experimental variability. Here we establish X-ray and blood-pool computed tomography (CT) contrast agent toxicity and teratogenesis thresholds for 3D Micro-CT imaging of live avian embryos. Day 4 chick embryos micro-injected with Visipaque™ (VP) developed for an additional 6 days without defect. X-ray radiation up to 798 mGy was nontoxic. Peak average contrast of 1,060 HU occurred within 1 hr of imaging at 50 μm resolution. VP-enhanced contrast persisted past 24 hr with delayed accumulation in the allantois. Regional volumes of VP-injected embryos were statistically identical to those of fixed embryos perfused with osmium tetroxide. We further quantified longitudinal volumetric morphogenesis of the allantois over 30 hr. These results demonstrate the safety and efficacy of contrast enhanced quantitative micro-CT imaging for live embryos.
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