ArticleThe EMBO journal1990
Interferon selectively inhibits the expression of mitochondrial genes: a novel pathway for interferon-mediated responses.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 91 citations in OpenAlex.
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- Baltic Sea coastal sediment-bound eukaryotes have increased year-round activities under predicted climate change related warming.Frontiers in microbiology · 2024Article
- The immune system as a driver of mitochondrial disease pathogenesis: a review of evidence.Orphanet journal of rare diseases · 2022Review
- Potential Anticarcinogenic Effects From Plasma of Older Adults After Exercise Training: An Exploratory Study.Frontiers in physiology · 2022Article
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- Innate Viral Sensor MDA5 and Coxsackievirus Interplay in Type 1 Diabetes Development.Microorganisms · 2020Review
- Interferon alpha: The key trigger of type 1 diabetes.Journal of autoimmunity · 2018Review
- PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing.The EMBO journal · 2017Article
- Article
- Interferons, signal transduction pathways, and the central nervous system.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2014Review
- Multi-tasking: nuclear transcription factors with novel roles in the mitochondria.Trends in cell biology · 2012Review
- Mitochondrial involvement in bladder function and dysfunction.Molecular and cellular biochemistry · 1999Review
- Transcription of mitochondrial and mitochondria-related nuclear genes in rabbit bladder following partial outlet obstruction.Molecular and cellular biochemistry · 1997Article
- Cytokine therapeutics: lessons from interferon alpha.Proceedings of the National Academy of Sciences of the United States of America · 1994Review
- Transcription of the yeast mitochondrial genome requires cyclic AMP.Molecular & general genetics : MGG · 1993Article
- Downregulation of interleukin 8 gene expression in human fibroblasts: unique mechanism of transcriptional inhibition by interferon.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
As an approach to identifying genes involved in physiological actions of interferons we used differential probes to screen a cDNA library from mouse L-929 cells treated with interferon alpha/beta. We identified two negatively regulated mRNA species which have been examined by analysis of the corresponding mRNAs and by DNA sequencing. Comparison with the GenBank database showed that these cDNA clones corresponded to mitochondrially encoded genes for cytochrome b and subunit I of cytochrome c oxidase. A further cDNA encompassing three mitochondrial genes was used as a probe to show that a third mRNA, NADH dehydrogenase subunit 5, was also down-regulated by interferon while a fourth, NADH dehydrogenase subunit 6, was unaffected. Expression of cytochrome b was also inhibited in mouse NIH 3T3 cells treated with interferon alpha/beta and in human Daudi lymphoblastoid cells treated with interferon alpha. The ability of interferon to reduce mitochondrial mRNA levels could be blocked by cycloheximide suggesting that these effects are mediated by an interferon-responsive nuclear gene which encodes a product capable of regulating mitochondrial gene expression. Analysis of proteins synthesized in the presence of emetine, a specific inhibitor of cytoplasmic translation, showed that the synthesis of several mitochondrial translation products, including cytochrome b, was reduced after treatment with interferon. Our results reveal a novel effect of interferon on cellular physiology which could have important consequences for understanding the effects of interferons as well as suggesting new mechanisms for the regulation of mitochondrial biogenesis and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.