ArticleHormones & cancer2011
Testosterone regulates tight junction proteins and influences prostatic autoimmune responses.
Article in Hormones & cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02734238 (Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery: a Randomized, Placebo Controlled Trial
Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- The Multifaceted Role of Androgen Receptor Signaling in Immunity: Implications for Oncology.Molecular cancer research : MCR · 2026Review
- Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection.Science (New York, N.Y.) · 2025Article
- The role of testosterone in men's health: is it time for a new approach?International urology and nephrology · 2022Review
- The Role of ZIP9 and Androgen Receptor in the Establishment of Tight Junctions between Adult Rat Sertoli Cells.Biology · 2022Article
- Article
- Altered selection on a single self-ligand promotes susceptibility to organ-specific T cell infiltration.The Journal of experimental medicine · 2021Article
- Multi-Omics Analysis Reveals Changes in the Intestinal Microbiome, Transcriptome, and Methylome in a Rat Model of Chronic Non-bacterial Prostatitis: Indications for the Existence of the Gut-Prostate Axis.Frontiers in physiology · 2021Article
- Host Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious Diseases.Frontiers in microbiology · 2021Review
- Review
- The Expression and Prognostic Significance of Claudin-8 and Androgen Receptor in Breast Cancer.OncoTargets and therapy · 2020Article
- Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen.Immunity · 2017Article
- CLDN8, an androgen-regulated gene, promotes prostate cancer cell proliferation and migration.Cancer science · 2017Article
- Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor.Molecular cell · 2016Article
- Predictors and clinical consequences of starting androgen therapy in men with low testosterone: results from the SIAMO-NOI registry.Journal of endocrinological investigation · 2016Observational
- The Roles of Tight Junctions and Claudin-1 in the Microbubble-Mediated Ultrasound-Induced Enhancement of Drug Concentrations in Rat Prostate.The Journal of membrane biology · 2015Article
- Histopathological classification criteria of rat model of chronic prostatitis/chronic pelvic pain syndrome.International urology and nephrology · 2015Article
- Minireview: Steroid/nuclear receptor-regulated dynamics of occluding and anchoring junctions.Molecular endocrinology (Baltimore, Md.) · 2014Review
- Male accessory gland infection: relevance of serum total testosterone levels.International journal of endocrinology · 2014Article
- Article
- A novel murine model of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) induced by immunization with a spermine binding protein (p25) peptide.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Testosterone and inflammation have been linked to the development of common age-associated diseases affecting the prostate gland including prostate cancer, prostatitis, and benign prostatic hypertrophy. We hypothesized that testosterone regulates components of prostate tight junctions which serve as a barrier to inflammation, thus providing a connection between age- and treatment-associated testosterone declines and prostatic pathology. We examined the expression and distribution of tight junction proteins in prostate biospecimens from mouse models and a clinical study of chemical castration, using transcript profiling, immunohistochemistry, and electron microscopy. We determined that low serum testosterone is associated with reduced transcript and protein levels of Claudin 4 and Claudin 8, resulting in defective tight junction ultrastructure in benign prostate glands. Expression of Claudin 4 and Claudin 8 was negatively correlated with the mononuclear inflammatory infiltrate caused by testosterone deprivation. Testosterone suppression also induced an autoimmune humoral response directed toward prostatic proteins. Testosterone supplementation in castrate mice resulted in re-expression of tight junction components in prostate epithelium and significantly reduced prostate inflammatory cell numbers. These data demonstrate that tight junction architecture in the prostate is related to changes in serum testosterone levels, and identify an androgen-regulated mechanism that potentially contributes to the development of prostate inflammation and consequent pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.