ReviewHormones & cancer2011
Aberrant activation of cell cycle regulators, centrosome amplification, and mitotic defects.
Review in Hormones & cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- KIFC1 depends on TRIM37-mediated ubiquitination of PLK4 to promote centrosome amplification in endometrial cancer.Cell death discovery · 2024Article
- HN1 interacts with γ-tubulin to regulate centrosomes in advanced prostate cancer cells.Cell cycle (Georgetown, Tex.) · 2021Article
- The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells.Scientific reports · 2021Article
- Polo-like kinase 4 mediates epithelial-mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway.Cell death & disease · 2018Article
- The E2F activators control multiple mitotic regulators and maintain genomic integrity through Sgo1 and BubR1.Oncotarget · 2017Article
- Centrosome amplification in chondrosarcomas: A primary cell culture and cryopreserved tumor sample study.Oncology letters · 2017Article
- PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastric cancer.Molecular biology reports · 2014Article
- LIS1 controls mitosis and mitotic spindle organization via the LIS1-NDEL1-dynein complex.Human molecular genetics · 2014Article
- Rho-kinase: regulation, (dys)function, and inhibition.Biological chemistry · 2013Review
- RABL6A, a novel RAB-like protein, controls centrosome amplification and chromosome instability in primary fibroblasts.PloS one · 2013Article
- Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis.Cell cycle (Georgetown, Tex.) · 2012Article
- In vivo tumorigenesis was observed after injection of in vitro expanded neural crest stem cells isolated from adult bone marrow.PloS one · 2012Article
- Gene expression profiles are altered in human papillomavirus-16 E6 D25E-expressing cell lines.Virology journal · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The centrosome that functions as a microtubule organizing center of a cell plays a key role in formation of bipolar mitotic spindles. Cells normally have either one (unduplicated) or two (duplicated) centrosomes. However, loss of the mechanisms controlling the numeral integrity of centrosomes leads to centrosome amplification (presence of more than two centrosomes), primarily via overduplication or fragmentation of centrosomes, resulting in defective mitosis and consequentially chromosome instability. Centrosome amplification frequently occurs in various cancers, and is considered as a major cause of chromosome instability. It has recently been found that ROCK2 kinase plays a critical role in promotion of centrosome duplication and amplification. Considering that ROCK2 is activated by Rho protein, and Rho is the immediate downstream target of many growth and hormone receptors, it is possible that such receptors may rather directly affect centrosome duplication and amplification. Indeed, constitutive activation of the receptors known to signal to the Rho pathway leads to promotion of centrosome amplification and chromosome instability in the Rho-ROCK2 pathway-dependent manner. These observations reveal an unexplored, yet important, oncogenic activities of those receptors in carcinogenesis; destabilizing chromosomes through promotion of centrosome amplification via continual activation of the Rho-ROCK2 pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.