ArticleCerebellum (London, England)2011
STD-dependent and independent encoding of input irregularity as spike rate in a computational model of a cerebellar nucleus neuron.
Article in Cerebellum (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 27 citations in OpenAlex.
- Functional Characterization of Four Known Cav2.1 Variants Associated with Neurodevelopmental Disorders.Membranes · 2023Article
- Transcranial direct current stimulation of cerebellum alters spiking precision in cerebellar cortex: A modeling study of cellular responses.PLoS computational biology · 2021Article
- Article
- Contribution of Somatic and Dendritic SK Channels in the Firing Rate of Deep Cerebellar Nuclei: Implication in Cerebellar Ataxia.Basic and clinical neuroscience · 2016Article
- Modeling the Cerebellar Microcircuit: New Strategies for a Long-Standing Issue.Frontiers in cellular neuroscience · 2016Review
- Distribution of N-Acetylgalactosamine-Positive Perineuronal Nets in the Macaque Brain: Anatomy and Implications.Neural plasticity · 2016Article
- A Recurrent Mutation in CACNA1G Alters Cav3.1 T-Type Calcium-Channel Conduction and Causes Autosomal-Dominant Cerebellar Ataxia.American journal of human genetics · 2015Article
- Flocculus Purkinje cell signals in mouse Cacna1a calcium channel mutants of escalating severity: an investigation of the role of firing irregularity in ataxia.Journal of neurophysiology · 2014Article
- Modeling the generation of output by the cerebellar nuclei.Neural networks : the official journal of the International Neural Network Society · 2013Review
- A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets.The Journal of physiology · 2013Article
- Strength and timing of motor responses mediated by rebound firing in the cerebellar nuclei after Purkinje cell activation.Frontiers in neural circuits · 2013Article
- 4-aminopyridine does not enhance flocculus function in tottering, a mouse model of vestibulocerebellar dysfunction and ataxia.PloS one · 2013Article
- Synchrony and neural coding in cerebellar circuits.Frontiers in neural circuits · 2012Article
- The cerebellar nuclei take center stage.Cerebellum (London, England) · 2011Article
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7 authors at 3 institutions in 2 countries.
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Abstract
Neurons in the cerebellar nuclei (CN) receive inhibitory inputs from Purkinje cells in the cerebellar cortex and provide the major output from the cerebellum, but their computational function is not well understood. It has recently been shown that the spike activity of Purkinje cells is more regular than previously assumed and that this regularity can affect motor behaviour. We use a conductance-based model of a CN neuron to study the effect of the regularity of Purkinje cell spiking on CN neuron activity. We find that increasing the irregularity of Purkinje cell activity accelerates the CN neuron spike rate and that the mechanism of this recoding of input irregularity as output spike rate depends on the number of Purkinje cells converging onto a CN neuron. For high convergence ratios, the irregularity induced spike rate acceleration depends on short-term depression (STD) at the Purkinje cell synapses. At low convergence ratios, or for synchronised Purkinje cell input, the firing rate increase is independent of STD. The transformation of input irregularity into output spike rate occurs in response to artificial input spike trains as well as to spike trains recorded from Purkinje cells in tottering mice, which show highly irregular spiking patterns. Our results suggest that STD may contribute to the accelerated CN spike rate in tottering mice and they raise the possibility that the deficits in motor control in these mutants partly result as a pathological consequence of this natural form of plasticity.
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