ArticleMolecular biology reports2012
Novel SNPs in the PRDM16 gene and their associations with performance traits in chickens.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 67 citations in OpenAlex.
- Association of aAnimals : an open access journal from MDPI · 2026Article
- Growth-Associated SNPs of theAnimals : an open access journal from MDPI · 2026Article
- Genetic Effects of ChickenAnimals : an open access journal from MDPI · 2025Article
- Genetic assessment and Identification of genes related to characterization of Guangdong local goose breeds based on modern and historical genomes.Communications biology · 2025Article
- Integrative genetic and epigenetic control of skeletal muscle fiber traits in agricultural animals.Frontiers in genetics · 2025Review
- Genetic architecture and key regulatory genes of fatty acid composition in Gushi chicken breast muscle determined by GWAS and WGCNA.BMC genomics · 2023Article
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- Genomic insight into the influence of selection, crossbreeding, and geography on population structure in poultry.Genetics, selection, evolution : GSE · 2023Article
- Heterogeneity of a dwarf phenotype in Dutch traditional chicken breeds revealed by genomic analyses.Evolutionary applications · 2021Article
- Genome-wide association study reveals the genetic determinism of growth traits in a Gushi-Anka FHeredity · 2021Article
- A Missense Mutation in theFrontiers in genetics · 2021Article
- Accumulation of genetic variants associated with immunity in the selective breeding of broilers.BMC genetics · 2020Article
- Identification and association of novel lncRNA pouMU1 gene mutations with chicken performance traits.Journal of genetics · 2017Article
- Effect ofAsian-Australasian journal of animal sciences · 2017Article
- Association study of a common genetic variant in pre-miR-1596 with chicken performance traits.Molecular biology reports · 2014Article
- Molecular cloning and SNP association analysis of chicken PMCH gene.Molecular biology reports · 2013Article
- MicroRNAs-1614-3p gene seed region polymorphisms and association analysis with chicken production traits.Journal of applied genetics · 2013Article
- Cloning of TPO gene and associations of polymorphisms with chicken growth and carcass traits.Molecular biology reports · 2013Article
- Genome-wide patterns of genetic variation in two domestic chickens.Genome biology and evolution · 2013Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The PR domain containing 16 (PRDM16) is a member of the Prdm family, and is known to regulate cell differentiation. In the present study, DNA pool sequencing methods were employed to screen genetic variations in the chicken PRDM16 gene. The results revealed four novel single nucleotide polymorphisms (SNPs): NC_006108.2: g.92188G>A, XM_417551: c.1161C>T (Ala/Ala, 387aa), c.1233C>T (Ser/Ser, 411aa) and c.1433G>A (Ser/Asn, 478aa). The BglI polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect c.1161C>T, while HhaI Forced PCR-RFLP methods were used to detect 1233C>T and c.1433G>A in 964 chickens. The chickens comprised 38 grandparents, 66 F(1) parents and 860 F(2) birds derived from an F(2) resource population of Gushi chickens crossed with Anka broilers. The associations of the polymorphisms in the chicken PRDM16 gene with performance traits were analyzed in the 860 F(2) chickens. The results indicated that the three SNPs were significantly associated with growth, fatness and meat quality traits in the chickens. In particular, the polymorphisms of the missense SNP (c.1433G>A) had positive effects on chicken body weight and body size at different stages. It affected also fatness traits significantly. Comparison of the different genotypes of c.1433G>A showed that the GG genotype favored chicken growth and fatness traits.
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