ArticleTranslational psychiatry2011
The neuroscience of suicidal behaviors: what can we expect from endophenotype strategies?
Article in Translational psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02843997 (Endophenotype Characterization of a Family Psychiatric Disorder of the Bipolar Spectrum, With an Autosomal Dominant Expression), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Endophenotype Characterization of a Family Psychiatric Disorder of the Bipolar Spectrum, With an Autosomal Dominant Expression
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 147 citations in OpenAlex.
- Suicidal Risk in Women with Premenstrual Syndrome and Premenstrual Dysphoric Disorder: A Systematic Review and Meta-Analysis.Journal of women's health (2002) · 2021Pooled it
- Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders.Scientific reports · 2021Trial
- Staging of suicidality in bipolar disorder: Findings from the FACE-BD cohort (FondaMental Advanced Centers of Expertise for Bipolar Disorders).European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Dissociated deficits of anticipated and experienced regret in at-risk suicidal individuals.Frontiers in psychiatry · 2023Article
- The Effectiveness of Predicting Suicidal Ideation through Depressive Symptoms and Social Isolation Using Machine Learning Techniques.Journal of personalized medicine · 2022Article
- MicroRNAs as novel peripheral markers for suicidality in patients with major depressive disorder.Frontiers in psychiatry · 2022Article
- Sex-based changes in rat brain serotonin and behavior in a model of altitude-related vulnerability to treatment-resistant depression.Psychopharmacology · 2021Article
- Modeling endophenotypes of suicidal behavior in animals.Neuroscience and biobehavioral reviews · 2021Review
- Detecting suicidal risk using MMPI-2 based on machine learning algorithm.Scientific reports · 2021Article
- Sleep complaints are associated with increased suicide risk independently of psychiatric disorders: results from a national 3-year prospective study.Molecular psychiatry · 2021Article
- Exploring the boundaries between borderline personality disorder and suicidal behavior disorder.European archives of psychiatry and clinical neuroscience · 2020Article
- An Intolerable Burden: Suicide, Intended Self-Injury and Diabetes.Canadian journal of diabetes · 2020Article
- Connectome Analysis of Brain Functional Network Alterations in Depressive Patients with Suicidal Attempt.Journal of clinical medicine · 2019Article
- Overlapping genetic effects between suicidal ideation and neurocognitive functioning.Journal of affective disorders · 2019Article
- Gray Matter Volume Reductions Were Associated with TPH1 Polymorphisms in Depressive Disorder Patients with Suicidal Attempts.Psychiatry investigation · 2018Article
- Neurocognitive Function and Suicide in U.S. Army Soldiers.Suicide & life-threatening behavior · 2017Article
- Animal models to improve our understanding and treatment of suicidal behavior.Translational psychiatry · 2017Review
- The experience of social exclusion in women with a history of suicidal acts: a neuroimaging study.Scientific reports · 2017Article
- SKA2 methylation is associated with decreased prefrontal cortical thickness and greater PTSD severity among trauma-exposed veterans.Molecular psychiatry · 2016Article
- Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
Vulnerability to suicidal behavior (SB) is likely mediated by an underlying genetic predisposition interacting with environmental and probable epigenetic factors throughout the lifespan to modify the function of neuronal circuits, thus rendering an individual more likely to engage in a suicidal act. Improving our understanding of the neuroscience underlying SBs, both attempts and completions, at all developmental stages is crucial for more effective preventive treatments and for better identification of vulnerable individuals. Recent studies have characterized SB using an endophenotype strategy, which aims to identify quantitative measures that reflect genetically influenced stable changes in brain function. In addition to aiding in the functional characterization of susceptibility genes, endophenotypic research strategies may have a wider impact in determining vulnerability to SB, as well as the translation of human findings to animal models, and vice versa. Endophenotypes associated with vulnerability to SB include impulsive/aggressive personality traits and disadvantageous decision making. Deficits in realistic risk evaluation represent key processes in vulnerability to SB. Serotonin dysfunction, indicated by neuroendocrine responses and neuroimaging, is also strongly implicated as a potential endophenotype and is linked with impulsive aggression and disadvantageous decision making. Specific endophenotypes may represent heritable markers for the identification of vulnerable patients and may be relevant targets for successful suicide prevention and treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.