ArticlePediatric allergy, immunology, and pulmonology2010
Severe Asthma in Children: Insights from the National Heart, Lung, and Blood Institute's Severe Asthma Research Program.
Article in Pediatric allergy, immunology, and pulmonology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- Review
- Clinical significance of the bronchodilator response in children with severe asthma.Pediatric pulmonology · 2019Article
- Asthma and Corticosteroid Responses in Childhood and Adult Asthma.Clinics in chest medicine · 2019Review
- Inflammatory and Comorbid Features of Children Admitted to a PICU for Status Asthmaticus.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2018Article
- Translating Asthma: Dissecting the Role of Metabolomics, Genomics and Personalized Medicine.Indian journal of pediatrics · 2018Article
- Pediatric severe asthma: a case series report and perspectives on anti-IgE treatment.BMC pediatrics · 2018Review
- Asthma: Differential Diagnosis and Comorbidities.Frontiers in pediatrics · 2018Review
- Stratified approaches to the treatment of asthma.British journal of clinical pharmacology · 2013Review
- Phenotypes and endotypes of severe asthma in children.Korean journal of pediatrics · 2013Article
- Poor asthma control in obese children may be overestimated because of enhanced perception of dyspnea.The journal of allergy and clinical immunology. In practice · 2013Article
- Severe asthma in childhood: recent advances in phenotyping and pathogenesis.Current opinion in allergy and clinical immunology · 2012Review
- Airway TGF-β1 and oxidant stress in children with severe asthma: association with airflow limitation.The Journal of allergy and clinical immunology · 2012Article
- Associations of Fraction of Exhaled Nitric Oxide with Beta Agonist Use in Children with Asthma.Pediatric allergy, immunology, and pulmonology · 2011Article
- Advances in pediatric asthma in 2010: addressing the major issues.The Journal of allergy and clinical immunology · 2011Review
- Severe Asthma in Children: Lessons Learned and Future Directions.The journal of allergy and clinical immunology. In practiceReview
- Severe asthma in children.The journal of allergy and clinical immunology. In practiceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Severe asthma in children is a complicated disorder characterized by ongoing symptoms and persistent airway inflammation despite treatment with high doses of inhaled and oral corticosteroids. Although knowledge of asthma and its associated mechanisms has increased substantially over the past decade, significant gaps remain about the determinants of severe asthma in children and the progression of the disorder across the lifespan. This review highlights recent insights into severe asthma in children derived from the National Heart, Lung, and Blood Institute's Severe Asthma Research Program (SARP), with an emphasis on age-specific findings and differences from severe asthma in adults. While the existence of a true severe asthma phenotype in children is subject to some debate, given the results of SARP and other investigators, we conclude that there is indeed a subgroup of children with severe asthma who have extreme morbidity and differentiating clinical features that are identifiable very early in life. However, unlike adults with severe asthma, children with severe asthma are more likely to fall in a more narrow cluster that is characterized by marked atopy and reversible airflow obstruction. While SARP has advanced knowledge of severe asthma in children, considerable gaps remain for which additional studies are needed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.