ArticleInternational journal of Alzheimer's disease2011
Association between the c. 2495 A>G ATP7B Polymorphism and Sporadic Alzheimer's Disease.
Article in International journal of Alzheimer's disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Exposure of metal toxicity in Alzheimer's disease: An extensive review.Frontiers in pharmacology · 2022Review
- Agricultural Use of Copper and Its Link to Alzheimer's Disease.Biomolecules · 2020Review
- Single nucleotide polymorphisms in the human ATP7B gene modify the properties of the ATP7B protein.Metallomics : integrated biometal science · 2019Article
- Does Ceruloplasmin Defend Against Neurodegenerative Diseases?Current neuropharmacology · 2019Review
- Non-Ceruloplasmin Copper Distincts Subtypes in Alzheimer's Disease: a Genetic Study of ATP7B Frequency.Molecular neurobiology · 2017Article
- Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer's Disease.Frontiers in molecular neuroscience · 2017Review
- Estrogen intake and copper depositions: implications for Alzheimer's disease?Case reports in neurology · 2014Article
- Alzheimer's disease causation by copper toxicity and treatment with zinc.Frontiers in aging neuroscience · 2014Article
- ATP7B variants as modulators of copper dyshomeostasis in Alzheimer's disease.Neuromolecular medicine · 2013Article
- Linkage disequilibrium and haplotype analysis of the ATP7B gene in Alzheimer's disease.Rejuvenation research · 2013Article
- Role of the P-Type ATPases, ATP7A and ATP7B in brain copper homeostasis.Frontiers in aging neuroscience · 2013Article
- Copper phenotype in Alzheimer's disease: dissecting the pathway.American journal of neurodegenerative disease · 2013Article
- Zinc deficiency and zinc therapy efficacy with reduction of serum free copper in Alzheimer's disease.International journal of Alzheimer's disease · 2013Review
- Impairment of interrelated iron- and copper homeostatic mechanisms in brain contributes to the pathogenesis of neurodegenerative disorders.Frontiers in pharmacology · 2012Article
- Paradigm shift in treatment of Alzheimer's disease: zinc therapy now a conscientious choice for care of individual patients.International journal of Alzheimer's disease · 2011Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonceruloplasmin-bound copper ("free") is reported to be elevated in Alzheimer's disease (AD). In Wilson's disease (WD) Cu-ATPase 7B protein tightly controls free copper body levels. To explore whether the ATP7B gene harbours susceptibility loci for AD, we screened 180 AD chromosomes for sequence changes in exons 2, 5, 8, 10, 14, and 16, where most of the Mediterranean WD-causing mutations lie. No WD mutation, but sequence changes corresponding to c.1216 T>G Single-Nucleotide Polymorphism (SNP) and c.2495 A>G SNP were found. Thereafter, we genotyped 190 AD patients and 164 controls for these SNPs frequencies estimation. Logistic regression analyses revealed either a trend for the c.1216 SNP (P = .074) or a higher frequency for c.2495 SNP of the GG genotype in patients, increasing the probability of AD by 74% (P = .028). Presence of the GG genotype in ATP7B c.2495 could account for copper dysfunction in AD which has been shown to raise the probability of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.