ArticleInternational journal of Alzheimer's disease2011
The default mode network in healthy aging and Alzheimer's disease.
Article in International journal of Alzheimer's disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
152 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- What are the neural correlates of meta-cognition and anosognosia in Alzheimer's disease? A systematic review.Neurobiology of aging · 2020Pooled it
- Resting State Abnormalities of the Default Mode Network in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.Journal of Alzheimer's disease : JAD · 2019Pooled it
- Facial Emotion Recognition Ability May Improve in Alzheimer Disease: A Pilot Study.Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2026Trial
- Trial
- APOE ε4-related structural vulnerability in mild cognitive impairment: a subsystem-based analysis of the default mode network.Research square · 2026Article
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Association between processing speed and segregation/integration of large-scale functional networks in middle-aged and older people living with HIV.BMC neurology · 2026Article
- Modelling cognitive outcomes in the UK Biobank: Education, noradrenaline and frontoparietal networks.PloS one · 2026Article
- Age-related degradation of behavioral and network features ofFrontiers in aging neuroscience · 2026Article
- The Impact of Insulin Resistance on Grey Matter Changes Along the Alzheimer's Disease Continuum Insulin Resistance and Grey Matter in AD.medRxiv : the preprint server for health sciences · 2025Article
- Age-related degradation of behavioral and network features ofbioRxiv : the preprint server for biology · 2025Article
- Poor dream recall associates with Alzheimer's disease biomarkers and dementia risk.medRxiv : the preprint server for health sciences · 2025Article
- The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Neurophysiological Progression in Alzheimer's Disease: Insights From Dynamic Causal Modelling of Longitudinal Magnetoencephalography.Human brain mapping · 2025Article
- Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer's disease.Science advances · 2025Article
- Analysis of functional connectivity changes from childhood to old age: A study using HCP-D, HCP-YA, and HCP-A datasets.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Variation in brain aging: A review and perspective on the utility of individualized approaches to the study of functional networks in aging.Neurobiology of aging · 2025Review
- Article
- Event-related potential markers of subjective cognitive decline and mild cognitive impairment during a sustained visuo-attentive task.NeuroImage. Clinical · 2025Article
92 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the past decade, a "default mode network" (DMN) has been highlighted in neuroimaging studies as a set of brain regions showing increased activity in task-free state compared to cognitively demanding task, and synchronized activity at rest. Changes within this network have been described in healthy aging as well as in Alzheimer's disease (AD) and populations at risk for AD, that is, amnestic Mild Cognitive Impairment (aMCI) patients and APOE-ε4 carriers. This is of particular interest in the context of early diagnosis and more generally for our understanding of the physiopathological mechanisms of AD. This paper gives an overview of the anatomical and physiological characteristics of this network as well as its relationships with cognition, before focusing on changes in the DMN over normal aging and Alzheimer's disease. While perturbations of the DMN have been consistently reported, especially within the posterior cingulate, further studies are needed to understand their clinical implication.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.