ArticlePloS one2011
Novel characterization of lymphatic valve formation during corneal inflammation.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Vascular smooth muscle- and myeloid cell-derived integrin α9β1 does not directly mediate the development of atherosclerosis in mice.Atherosclerosis · 2022Article
- Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43.Developmental biology · 2017Article
- Integrin Alpha 9 Blockade Suppresses Lymphatic Valve Formation and Promotes Transplant Survival.Investigative ophthalmology & visual science · 2016Article
- Intravital Imaging Reveals Dynamics of Lymphangiogenesis and Valvulogenesis.Scientific reports · 2016Article
- Integrin Alpha-9 Mediates Lymphatic Valve Formation in Corneal Lymphangiogenesis.Investigative ophthalmology & visual science · 2015Article
- Role of angiopoietin-2 in corneal lymphangiogenesis.Investigative ophthalmology & visual science · 2014Article
- Corneal lymphatic valve formation in relation to lymphangiogenesis.Investigative ophthalmology & visual science · 2014Article
- Article
- An in vivo method for visualizing flow dynamics of cells within corneal lymphatics.Lymphatic research and biology · 2013Article
- Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation.The American journal of pathology · 2012Article
- Conjunctival lymphatic response to corneal inflammation in mice.Journal of ophthalmology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Lymphatic research has progressed rapidly in recent years. Though lymphatic dysfunction has been found in a wide array of disorders from transplant rejection to cancer metastasis, to date, there is still little effective treatment for lymphatic diseases. The cornea offers an optimal site for lymphatic research due to its accessible location, transparent nature, and lymphatic-free but inducible features. However, it still remains unknown whether lymphatic valves exist in newly formed lymphatic vessels in the cornea, and how this relates to an inflammatory response. In this study, we provide the first evidence showing that lymphatic valves were formed in mouse cornea during suture-induced inflammation with the up-regulation of integrin alpha 9. The number of corneal valves increased with the progression of inflammatory lymphangiogenesis. Moreover, we have detected lymphatic valves at various developmental stages, from incomplete to more developed ones. In addition to defining the average diameter of lymphatic vessels equipped with lymphatic valves, we also report that lymphatic valves were more often located near the branching points. Taken together, these novel findings not only provide new insights into corneal lymphatic formation and maturation, but also identify a new model for future investigation on lymphatic valve formation and possibly therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.