Evidence map›Paper›PMID 21760831›Full record

ArticleSoft matter2011

Mechanical robustness of Pseudomonas aeruginosa biofilms.

Oliver Lieleg, Marina Caldara, Regina Baumgärtel, Katharina Ribbeck

Open access · bronzeAbstract read
In one paragraph

Article in Soft matter, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. The EPS-I exopolysaccharide transformsProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Mechanical Comparison ofACS biomaterials science & engineering · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Biofilm aggregates and the host airway-microbial interface.Frontiers in cellular and infection microbiology · 2022
    Review
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Oliver LielegDepartment of Biological Engineering, Massachusetts Institute of Technology, 500 Technology Square, Cambridge, MA 02139.
Marina Caldara
Regina Baumgärtel
Katharina Ribbeck
Massachusetts Institute of Technology · US

Funding

THEORETICAL ANALYSIS OF FUNCTIONAL MODULESP50GM068763 · NIGMS · HARVARD UNIVERSITY · PI STERN, BODO · 2003 to 2012
$28.9M
TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NILES, JACQUIN C · 1985 to 2020
$25.6M
NIEHS NIH HHS P30 ES002109NIGMS NIH HHS P50 GM068763
6 · The paper itself

Abstract

Biofilms grow on various surfaces and in many different environments, a phenomenon that constitutes major problems in industry and medicine. Despite their importance little is known about the viscoelastic properties of biofilms and how these depend on the chemical microenvironment. Here, we find that the mechanical properties of Pseudomonas aeruginosa (P.a.) biofilms are highly robust towards chemical perturbations. Specifically, we observe that P.a. biofilms are able to fully regain their initial stiffness after yielding is enforced, even in the presence of chemicals. Moreover, only trivalent ions and citric acid significantly affect the biofilm elasticity, the first of which also alter the texture of the material. Finally, our results indicate that biofilm mechanics and bacteria viability inside the biofilm are not necessarily linked which suggests that targeting bacteria alone might not be sufficient for biofilm removal strategies.

Identifiers

PMID21760831
PMCPMC3134232
OpenAlexW1575654430

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.