ArticleJournal of tropical medicine2011
Matrix Metalloproteinase-9 and Haemozoin: Wedding Rings for Human Host and Plasmodium falciparum Parasite in Complicated Malaria.
Article in Journal of tropical medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 65 citations in OpenAlex.
- Myeloperoxidase and Other Markers of Neutrophil Activation Associate With Malaria and Malaria/HIV Coinfection in the Human Placenta.Frontiers in immunology · 2021Trial
- Mechanisms of parasite-mediated disruption of brain vessels.FEBS letters · 2026Review
- Article
- Apoptotic changes and aquaporin-1 expression in the choroid plexus of cerebral malaria patients.Malaria journal · 2022Article
- Triticum vulgare Extract Modulates Protein-Kinase B and Matrix Metalloproteinases 9 Protein Expression in BV-2 Cells: Bioactivity on Inflammatory Pathway Associated with Molecular Mechanism Wound Healing.Mediators of inflammation · 2020Article
- Genesis of placental sequestration in malaria and possible targets for drugs for placental malaria.Birth defects research · 2019Review
- Brain vascular heterogeneity: implications for disease pathogenesis and design of in vitro blood-brain barrier models.Fluids and barriers of the CNS · 2018Review
- Host matrix metalloproteinases in cerebral malaria: new kids on the block against blood-brain barrier integrity?Fluids and barriers of the CNS · 2014Article
- Effect of malaria components on blood mononuclear cells involved in immune response.Asian Pacific journal of tropical biomedicine · 2013Review
- Plasmodium coatneyi in rhesus macaques replicates the multisystemic dysfunction of severe malaria in humans.Infection and immunity · 2013Article
- New biomarkers for stage determination in Trypanosoma brucei rhodesiense sleeping sickness patients.Clinical and translational medicine · 2013Article
- Natural haemozoin induces expression and release of human monocyte tissue inhibitor of metalloproteinase-1.PloS one · 2013Article
- Haemozoin induces early cytokine-mediated lysozyme release from human monocytes through p38 MAPK- and NF-kappaB-dependent mechanisms.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is generally accepted that the combination of both Plasmodium falciparum parasite and human host factors is involved in the pathogenesis of complicated severe malaria, including cerebral malaria (CM). Among parasite products, the malarial pigment haemozoin (HZ) has been shown to impair the functions of mononuclear and endothelial cells. Different CM models were associated with enhanced levels of matrix metalloproteinases (MMPs), a family of proteolytic enzymes able to disrupt subendothelial basement membrane and tight junctions and shed, activate, or inactivate cytokines, chemokines, and other MMPs through cleavage from their precursors. Among MMPs, a good candidate for targeted therapy might be MMP-9, whose mRNA and protein expression enhancement as well as direct proenzyme activation by HZ have been recently investigated in a series of studies by our group and others. In the present paper the role of HZ and MMP-9 in complicated malaria, as well as their interactions, will be discussed.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.