Evidence map›Paper›PMID 21760758›Full record

ArticleJournal of chemical theory and computation2006

A New Method for Coarse-Grained Elastic Normal-Mode Analysis.

Mingyang Lu, Billy Poon, Jianpeng Ma

Abstract read
In one paragraph

Article in Journal of chemical theory and computation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
  2. Article
  3. Statistical learning of protein elastic network from positional covariance matrix.Computational and structural biotechnology journal · 2023
    Article
  4. Article
  5. Protein dynamics developments for the large scale and cryoEM: case study of ProDy 2.0.Acta crystallographica. Section D, Structural biology · 2022
    Review
  6. Article
  7. Article
  8. Journal of applied crystallography · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. FlexE: Using elastic network models to compare models of protein structure.Journal of chemical theory and computation · 2012
    Article
  20. fSUB: normal mode analysis with flexible substructures.The journal of physical chemistry. B · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mingyang LuDepartment of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, BCM-125, Houston, Texas 77030.
Billy Poon
Jianpeng Ma

Funding

New Simulation Methods at Multi-Scales and -ResolutionsR01GM067801 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI MA, JIANPENG · 2003 to 2015
$3.4M
NIGMS NIH HHS R01 GM067801
6 · The paper itself

Abstract

In this paper, we report a new method for coarse-grained elastic normal-mode analysis. The purpose is to overcome a long-standing problem in the conventional analysis called the tip effect that makes the motional patterns (eigenvectors) of some low-frequency modes irrational. The new method retains the merits of a conventional method such as not requiring lengthy initial energy minimization, which always distorts structures, and also delivers substantially more accurate low-frequency modes with no tip effect for proteins of any size. This improvement of modes is crucial for certain types of applications such as structural refinement or normal-mode-based sampling.

Identifiers

PMID21760758
PMCPMC3133770

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.