ArticleEMBO reports2011
A new factor in the Aedes aegypti immune response: CLSP2 modulates melanization.
Article in EMBO reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Insights on the sex determination, vector capacity and ecological biology from a chromosomal level genome of vector mosquito, Armigeres subulbatus.Infectious diseases of poverty · 2025Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2025Article
- A C-type lectin in saliva of Aedes albopictus (Diptera: Culicidae) bind and agglutinate microorganisms with broad spectrum.Journal of insect science (Online) · 2023Article
- Functional Analysis of a Multiple-Domain CTL15 in the Innate Immunity, Eclosion, and Reproduction ofCells · 2023Article
- Impacts of fungal entomopathogens on survival and immune responses of Aedes albopictus and Culex pipiens mosquitoes in the context of native Wolbachia infections.PLoS neglected tropical diseases · 2021Article
- Insights Into the Immune Response of the Black Soldier Fly Larvae to Bacteria.Frontiers in immunology · 2021Article
- Article
- Comparative analysis of C-type lectin domain proteins in the ghost moth, Thitarodes xiaojinensis (Lepidoptera: Hepialidae).Insect science · 2019Article
- The C-Type Lectin Domain Gene Family inViruses · 2018Article
- Strain-specific pathogenicity and subversion of phenoloxidase activity in the mosquito Aedes aegypti by members of the fungal entomopathogenic genus Isaria.Scientific reports · 2018Article
- Entomopathogenic fungal infection leads to temporospatial modulation of the mosquito immune system.PLoS neglected tropical diseases · 2018Article
- Activation of Aedes aegypti prophenoloxidase-3 and its role in the immune response against entomopathogenic fungi.Insect molecular biology · 2017Article
- Dynamics of the Interaction between Cotton BollwormMolecular & cellular proteomics : MCP · 2017Article
- Dengue virus serotype 2 infection alters midgut and carcass gene expression in the Asian tiger mosquito, Aedes albopictus.PloS one · 2017Article
- Structural features, evolutionary relationships, and transcriptional regulation of C-type lectin-domain proteins in Manduca sexta.Insect biochemistry and molecular biology · 2015Article
- A Critical Role for CLSP2 in the Modulation of Antifungal Immune Response in Mosquitoes.PLoS pathogens · 2015Article
- Insect prophenoloxidase: the view beyond immunity.Frontiers in physiology · 2014Review
- Mosquito saliva serine protease enhances dissemination of dengue virus into the mammalian host.Journal of virology · 2014Article
- A compendium of molecules involved in vector-pathogen interactions pertaining to malaria.Malaria journal · 2013Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Microbial infections in the mosquito Aedes aegypti activate the newly identified CLSP1 and CLSP2 genes, which encode modular proteins composed of elastase-like serine protease and C-type lectin domains. These genes are predominantly regulated by the immune deficiency pathway, but also by the Toll pathway. Silencing of CLSP2, but not CLSP1, results in the activation of prophenoloxidase (PPO), the terminal enzyme in the melanization cascade, suggesting that CLSP2 is a negative modulator of this reaction. Haemolymph PPO activation is normally inhibited in the presence of Plasmodium parasites, but in CLSP2-depleted mosquitoes, the Plasmodium-induced block of melanization is reverted, and these mosquitoes are refractory to the parasite. Thus, CLSP2 is a new component of the mosquito immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.