Evidence map›Paper›PMID 21760600›Full record

ArticleKidney international2011

A GAP in our knowledge of vascular signaling in acute kidney injury.

David P Basile

Abstract readComment
PubMed Publisher
In one paragraph

Article in Kidney international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

David P BasileDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA. dpbasile@iupui.edu

Funding

Long-term effects of acute renal failureR01DK063114 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI David P. Basile · 2003 to 2026
$8.1M
NIDDK NIH HHS R01 DK063114
6 · The paper itself

Abstract

Injury resulting from ischemia-reperfusion injury is a multifactorial process involving compromised function in both the tubular and the vascular compartments. Multiple vasoactive compounds have been implicated in the profound vasoconstriction that occurs in response to ischemia-reperfusion injury, and many of these factors signal through common G protein-coupled receptors. The report by Siedlecki et al. highlights the important roles of RGS4, a GTPase-accelerating protein (GAP), in the regulation of vascular tone in the setting of acute kidney injury.

Indexed as

Renal CirculationVasoconstrictionAcute Kidney InjuryAnimalsGTP-Binding Protein alpha Subunits, Gq-G11KidneyMaleReperfusion InjuryRGS ProteinsGTP-Binding Protein alpha Subunits, Gq-G11RGS4 proteinRGS Proteins

Identifiers

PMID21760600

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.