ArticlePharmacology2011
Pharmacokinetics of fluoxetine in rhesus macaques following multiple routes of administration.
Article in Pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Chronic Fluoxetine Treatment Desensitizes Serotoninergic Inhibition of GABAergic Inputs and Intrinsic Excitability of Dorsal Raphe Serotonin Neurons.Brain sciences · 2025Article
- Pharmacokinetics and Pharmacodynamics: A Comprehensive Analysis of the Absorption, Distribution, Metabolism, and Excretion of Psychiatric Drugs.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Fluoxetine degrades luminance perceptual thresholds while enhancing motivation and reward sensitivity.Frontiers in pharmacology · 2023Article
- The selective serotonin reuptake inhibitor fluoxetine has direct effects on beta cells, promoting insulin secretion and increasing beta-cell mass.Diabetes, obesity & metabolism · 2022Article
- Sex and social status modify the effects of fluoxetine on socioemotional behaviors in Syrian hamsters and rhesus macaques.Pharmacology, biochemistry, and behavior · 2022Article
- The zebrafish (Danio rerio) anxiety test battery: comparison of behavioral responses in the novel tank diving and light-dark tasks following exposure to anxiogenic and anxiolytic compounds.Psychopharmacology · 2022Article
- Long-Term Fluoxetine Administration Causes Substantial Lipidome Alteration of the Juvenile Macaque Brain.International journal of molecular sciences · 2021Article
- Fluoxetine Can Inhibit SARS-CoV-2 In Vitro.Microorganisms · 2021Article
- Pre-reproductive stress in adolescent female rats alters oocyte microRNA expression and offspring phenotypes: pharmacological interventions and putative mechanisms.Translational psychiatry · 2021Article
- Fluoxetine Arrests Growth of the Model DiatomFrontiers in microbiology · 2020Article
- Pre-reproductive stress and fluoxetine treatment in rats affect offspring A-to-I RNA editing, gene expression and social behavior.Environmental epigenetics · 2018Article
- Fluoxetine Administration in Juvenile Monkeys: Implications for Pharmacotherapy in Children.Frontiers in pediatrics · 2018Review
- Regulation of emotional response in juvenile monkeys treated with fluoxetine: MAOA interactions.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2016Article
- Peer social interaction is facilitated in juvenile rhesus monkeys treated with fluoxetine.Neuropharmacology · 2016Article
- Article
- Robust presynaptic serotonin 5-HT(1B) receptor inhibition of the striatonigral output and its sensitization by chronic fluoxetine treatment.Journal of neurophysiology · 2015Article
- Pharmacokinetics of fluoxetine in pregnant baboons (Papio spp.).Journal of the American Association for Laboratory Animal Science : JAALAS · 2014Article
- Fluoxetine: juvenile pharmacokinetics in a nonhuman primate model.Psychopharmacology · 2014Article
- Fluoxetine and all other SSRIs are 5-HT2B Agonists - Importance for their Therapeutic Effects.Current neuropharmacology · 2014Article
- Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsFluoxetine (Prozac) is a selective serotonin reuptake inhibitor currently used to treat depression and mood disorders. It has been widely studied clinically and preclinically, yet there is limited knowledge of its pharmacokinetics in nonhuman primates.
methodsThe present study characterized the pharmacokinetics of fluoxetine and its active metabolite norfluoxetine in rhesus macaques following both acute (1, 3, 5.6 and 10 mg/kg) and chronic doses (5.6 and 10 mg/kg/day) via different routes of administration (intravenous, subcutaneous, intramuscular, and oral). Blood samples were collected at multiple time points following administration and analyzed using mass spectrometry.
resultsFluoxetine had a half-life of 11-16 h and norfluoxetine had a half-life of 21-29 h. Potentially functionally significant serum concentrations of norfluoxetine were present at 24 h even after a single administration of fluoxetine. Similar to observations in humans under steady state conditions, norfluoxetine accounted for the greater percentage of active drug in the blood stream.
conclusionA daily dose of 10 mg/kg administered orally maintained serum concentrations in the human clinical range over the course of 6 weeks. Given the long half-lives of fluoxetine and norfluoxetine observed in this study, precautions should be taken when designing preclinical studies to prevent accumulation of drug serum concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.