ArticleNeuroepidemiology2011
Inflammatory markers and neuropsychological functioning: the Framingham Heart Study.
Article in Neuroepidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The risk of dementia in breast cancer survivors: a meta-analysis of observational studies.Annals of medicine · 2025Pooled it
- Increase in the Inflammatory Marker GlycA over 13 Years in Young Adults Is Associated with Poorer Cognitive Function in Midlife.PloS one · 2015Trial
- Associations between immunosenescence and domain-specific cognition in the Health and Retirement Study Harmonized Cognitive Assessment Protocol.BMC biology · 2026Article
- Sleep duration and biomarkers of inflammation in African American and white participants with a parental history of Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Immune function, cortisol, and cognitive decline & dementia in an aging latino population.Psychoneuroendocrinology · 2021Observational
- Inflammation, Cognition, and White Matter in Older Adults: An Examination by Race.Frontiers in aging neuroscience · 2020Article
- The Modulatory Effect of Gender and Cytomegalovirus-Seropositivity on Circulating Inflammatory Factors and Cognitive Performance in Elderly Individuals.International journal of molecular sciences · 2019Article
- Depression, inflammation, and memory loss among Mexican Americans: analysis of the HABLE cohort.International psychogeriatrics · 2017Article
- [Image segmentation and classification of cytological cells based on multi-features clustering and chain splitting model].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2017Article
- Inflammation, Self-Regulation, and Health: An Immunologic Model of Self-Regulatory Failure.Perspectives on psychological science : a journal of the Association for Psychological Science · 2017Review
- Associations Between Serum Inflammatory Markers and Hippocampal Volume in a Community Sample.Journal of the American Geriatrics Society · 2016Article
- Glycemic control, inflammation, and cognitive function in older patients with type 2 diabetes.International journal of geriatric psychiatry · 2015Article
- Asthma control and cognitive function in a cohort of elderly adults.Journal of the American Geriatrics Society · 2015Article
- Adverse vascular risk is related to cognitive decline in older adults.Journal of Alzheimer's disease : JAD · 2015Article
- Possible neurocognitive benefits of exercise in persons with heart failure.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2015Review
- Associations between inflammation and cognitive function in African Americans and European Americans.Journal of the American Geriatrics Society · 2014Article
- Potential biomarkers relating pathological proteins, neuroinflammatory factors and free radicals in PD patients with cognitive impairment: a cross-sectional study.BMC neurology · 2014Article
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- Early Alzheimer's and Parkinson's disease pathology in urban children: Friend versus Foe responses--it is time to face the evidence.BioMed research international · 2013Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsWe hypothesized that inflammatory markers are cross-sectionally and longitudinally associated with neuropsychological indicators of early ischemia and Alzheimer's disease.
methodsFramingham Offspring Study participants, free of clinical stroke or dementia (n = 1,878; 60 ± 9 years; 54% women), underwent neuropsychological assessment and ascertainment of 11 inflammatory markers. Follow-up neuropsychological assessments (6.3 ± 1.0 years) were conducted on 1,352 of the original 1,878 participants.
resultsMultivariable linear regression related the inflammatory markers to cross-sectional performance and longitudinal change in neuropsychological performances. Secondary models included a twelfth factor, tumor necrosis factor-α (TNF-α), available on a subset of the sample (n = 1,393 cross-sectional; n = 1,213 longitudinal). Results suggest a few modest cross-sectional inflammatory and neuropsychological associations, particularly for tests assessing visual organization (C-reactive protein, p = 0.007), and a few modest relations between inflammatory markers and neuropsychological change, particularly for executive functioning (TNF-α, p = 0.004). Secondary analyses suggested that inflammatory markers were cross-sectionally (TNF-α, p = 0.004) related to reading performance.
conclusionsOur findings are largely negative, but suggest that specific inflammatory markers may have limited associations with poorer cognition and reading performance among community-dwelling adults. Because of multiple testing concerns, our limited positive findings are offered as hypothesis generating and require replication in other studies.
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