ArticleJournal of breath research2011
Clinical study of multiple breath biomarkers of asthma and COPD (NO, CO(2), CO and N(2)O) by infrared laser spectroscopy.
Article in Journal of breath research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Pulmonary biomarkers in COPD exacerbations: a systematic review.Respiratory research · 2013Pooled it
- Respirator-integrated continuous gas sampling for broadband optical spectroscopy.Scientific reports · 2026Article
- Facile Preparation of TiOSensors (Basel, Switzerland) · 2024Article
- Smelling the Disease: Diagnostic Potential of Breath Analysis.Molecular diagnosis & therapy · 2023Review
- Measurement of Exhaled Nitric Oxide in 456 Lung Cancer Patients Using a Ringdown FENO Analyzer.Metabolites · 2021Article
- Fractional Exhaled Nitric Oxide (FENO) in the management of asthma: a position paper of the Italian Respiratory Society (SIP/IRS) and Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC).Multidisciplinary respiratory medicine · 2020Article
- Use of Electronic Noses for Diagnosis of Digestive and Respiratory Diseases through the Breath.Biosensors · 2019Review
- Laser spectroscopy for breath analysis: towards clinical implementation.Applied physics. B, Lasers and optics · 2018Article
- Gas-phase broadband spectroscopy using active sources: progress, status, and applications.Journal of the Optical Society of America. B, Optical physics · 2017Article
- Fractional exhaled nitric oxide-measuring devices: technology update.Medical devices (Auckland, N.Z.) · 2016Review
- Normal values of exhaled carbon monoxide in healthy subjects: comparison between two methods of assessment.BMC pulmonary medicine · 2014Article
- Elevated carbon monoxide to carbon dioxide ratio in the exhaled breath of mice treated with a single dose of lipopolysaccharide.Open forum infectious diseases · 2014Article
- Association of serum Clara cell protein CC16 with respiratory infections and immune response to respiratory pathogens in elite athletes.Respiratory research · 2014Article
- Assessment of the exhalation kinetics of volatile cancer biomarkers based on their physicochemical properties.Journal of breath research · 2014Article
- Article
- Carbon monoxide in exhaled breath testing and therapeutics.Journal of breath research · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Breath analysis is a powerful non-invasive technique for the diagnosis and monitoring of respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD). Exhaled nitric oxide (NO) and carbon monoxide (CO) are markers of airway inflammation and can indicate the extent of respiratory diseases. We have developed a compact fast response quantum cascade laser system for analysis of multiple gases by tunable infrared absorption spectroscopy. The ARI breath analysis instrument has been deployed in a study of exhaled breath from patients with asthma or COPD. A total of 173 subjects participated, including both adult and pediatric patients. Patients in asthma or COPD exacerbations were evaluated twice-during the exacerbation and at a follow-up visit-to compare variations in breath biomarkers during these events. The change in exhaled NO levels between exacerbation and 'well' visits is consistent with spirometry data collected. Respiratory models are important for understanding the exchange dynamics of nitric oxide and other species in the lungs and airways. At each patient's visit, tests were conducted at four expiratory flow rates. We have applied a trumpet model with axial diffusion to the multi-flow exhaled nitric oxide data, obtaining NO alveolar concentrations and airway fluxes. We found higher airway fluxes for those with more severe asthma and during exacerbation events. The alveolar concentrations from the model were higher in adults with asthma and COPD, but this trend was less clear among the pediatric subjects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.