ArticleThe Journal of biological chemistry2011
Heightened induction of proapoptotic signals in response to endoplasmic reticulum stress in primary fibroblasts from a mouse model of longevity.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
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- Atypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice.Cell death & disease · 2023Article
- Control of Selective mRNA Translation in Neuronal Subcellular Compartments in Health and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Correlation of Significantly Decreased Serum Circulating Mesencephalic Astrocyte-Derived Neurotrophic Factor Level With an Increased Risk of Future Cardiovascular Disease in Adult Patients With Growth Hormone Deficiency.Frontiers in endocrinology · 2021Article
- Probing the unfolded protein response in long-lived naked mole-rats.Biochemical and biophysical research communications · 2020Article
- Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells.Biological research · 2019Article
- Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring.Molecular cell · 2019Article
- The IL-15-AKT-XBP1s signaling pathway contributes to effector functions and survival in human NK cells.Nature immunology · 2019Article
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- Proteostasis and ageing: insights from long-lived mutant mice.The Journal of physiology · 2017Review
- Role of interferon-γ and inflammatory monocytes in driving colonic inflammation during acute Clostridium difficile infection in mice.Immunology · 2017Article
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- The cell biology of aging.Molecular biology of the cell · 2015Review
- Interleukin-22 and CD160 play additive roles in the host mucosal response to Clostridium difficile infection in mice.Immunology · 2015Article
- The role of Gr-1(+) cells and tumour necrosis factor-α signalling during Clostridium difficile colitis in mice.Immunology · 2015Article
- Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Role of GM-CSF in the inflammatory cytokine network that regulates neutrophil influx into the colonic mucosa during Clostridium difficile infection in mice.Gut microbes · 2014Article
- Identification of genes promoting skin youthfulness by genome-wide association study.The Journal of investigative dermatology · 2014Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Previous work from our laboratory has shown that primary fibroblasts from long-lived Snell dwarf mice display a higher sensitivity to the lethal effects of endoplasmic reticulum (ER) stressors, such as thapsigargin, than cells from normal mice. Here we show that thapsigargin induces higher expression of CHOP, enhanced cleavage of caspase-12, higher caspase-3 activity, and increased phosphorylation of c-JUN, all indicators of enhanced apoptosis, in dwarf fibroblasts. Dwarf and normal fibroblasts show no genotypic difference in up-regulating BiP, GRP94, and ERp72 proteins after exposure to thapsigargin. However, dwarf fibroblasts express lower basal levels of a number of putative XBP1 target genes including Armet, Edem1, Erdj3, p58(IPK) and Sec61a1, as well as Ire1α itself. Furthermore, when exposed to thapsigargin, dwarf fibroblasts display attenuated splicing of Xbp1, but similar phosphorylation of eIF2α, in comparison to normal fibroblasts. These data support the notion that IRE1/XBP1 signaling is set at a lower level in dwarf fibroblasts. Diminished Xbp1 splicing in dwarf-derived fibroblasts may tilt the balance between prosurvival and proapoptotic signals in favor of apoptosis, thereby leading to higher induction of proapoptotic signals in these cells and ultimately their increased sensitivity to ER stressors. These results, together with recent findings in Caenorhabditis elegans daf-2 mutants, point to a potential interplay between insulin/IGF-1 signals and unfolded protein response signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.