ArticleMolecular biology of the cell2011
RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis.
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression.The Journal of cell biology · 2025Article
- Space omics research in Europe: Contributions, geographical distribution and ESA member state funding schemes.iScience · 2022Review
- Molecular subversion of Cdc42 signalling in cancer.Biochemical Society transactions · 2021Review
- Hindlimb Ischemia Impairs Endothelial Recovery and Increases Neointimal Proliferation in the Carotid Artery.Scientific reports · 2018Article
- FRET biosensor allows spatio-temporal observation of shear stress-induced polar RhoGDIα activation.Communications biology · 2018Article
- α3β1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway.Cancer research · 2016Article
- Article
- Extracting Diffusive States of Rho GTPase in Live Cells: Towards In Vivo Biochemistry.PLoS computational biology · 2015Article
- A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo.Scientific reports · 2015Article
- Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment.Oncotarget · 2015Article
- RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder Cancer.Molecular cancer research : MCR · 2015Article
- RhoC mediates epidermal growth factor-stimulated migration and invasion in head and neck squamous cell carcinoma.Neoplasia (New York, N.Y.) · 2015Article
- Rac1 GTPase silencing counteracts microgravity-induced effects on osteoblastic cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility.PloS one · 2013Article
- RhoC interacts with integrin α5β1 and enhances its trafficking in migrating pancreatic carcinoma cells.PloS one · 2013Article
- Integrated analysis of global mRNA and protein expression data in HEK293 cells overexpressing PRL-1.PloS one · 2013Article
- The faces and friends of RhoGDI2.Cancer metastasis reviews · 2012Review
- RhoB controls endothelial cell morphogenesis in part via negative regulation of RhoA.Vascular cell · 2012Article
- Rho proteins crosstalk via RhoGDIalpha: At random or hierarchically ordered?Communicative & integrative biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RhoGTPases are key signaling molecules regulating main cellular functions such as migration, proliferation, survival, and gene expression through interactions with various effectors. Within the RhoA-related subclass, RhoA and RhoC contribute to several steps of tumor growth, and the regulation of their expression affects cancer progression. Our aim is to investigate their respective contributions to the acquisition of an invasive phenotype by using models of reduced or forced expression. The silencing of RhoC, but not of RhoA, increased the expression of genes encoding tumor suppressors, such as nonsteroidal anti-inflammatory drug-activated gene 1 (NAG-1), and decreased migration and the anchorage-independent growth in vitro. In vivo, RhoC small interfering RNA (siRhoC) impaired tumor growth. Of interest, the simultaneous knockdown of RhoC and NAG-1 repressed most of the siRhoC-related effects, demonstrating the central role of NAG-1. In addition of being induced by RhoC silencing, NAG-1 was also largely up-regulated in cells overexpressing RhoA. The silencing of RhoGDP dissociation inhibitor α (RhoGDIα) and the overexpression of a RhoA mutant unable to bind RhoGDIα suggested that the effect of RhoC silencing is indirect and results from the up-regulation of the RhoA level through competition for RhoGDIα. This study demonstrates the dynamic balance inside the RhoGTPase network and illustrates its biological relevance in cancer progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.