ArticleJournal of lipid research2011
Linkage and association of phospholipid transfer protein activity to LASS4.
Article in Journal of lipid research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- A Dansyl-Modified Sphingosine Kinase Inhibitor DPF-543 Enhanced De Novo Ceramide Generation.International journal of molecular sciences · 2021Article
- Combination of Antimicrobial Starters for Feed Fermentation: Influence on Piglet Feces Microbiota and Health and Growth Performance, Including Mycotoxin BiotransformationFrontiers in veterinary science · 2020Article
- A genome-wide linkage study of autism spectrum disorder and the broad autism phenotype in extended pedigrees.Journal of neurodevelopmental disorders · 2018Article
- PBAP: a pipeline for file processing and quality control of pedigree data with dense genetic markers.Bioinformatics (Oxford, England) · 2015Article
- Next-generation gene discovery for variants of large impact on lipid traits.Current opinion in lipidology · 2015Review
- Identity-by-descent graphs offer a flexible framework for imputation and both linkage and association analyses.BMC proceedings · 2014Article
- Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia.American journal of human genetics · 2013Article
- GIGI: an approach to effective imputation of dense genotypes on large pedigrees.American journal of human genetics · 2013Article
- The role of large pedigrees in an era of high-throughput sequencing.Human genetics · 2012Review
- The genetics of familial combined hyperlipidaemia.Nature reviews. Endocrinology · 2012Review
- Identification of rare variants from exome sequence in a large pedigree with autism.Human heredity · 2012Article
- Reducing the exome search space for mendelian diseases using genetic linkage analysis of exome genotypes.Genome biology · 2011Article
- Estimation and visualization of identity-by-descent within pedigrees simplifies interpretation of complex trait analysis.Human heredity · 2011Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Phospholipid transfer protein activity (PLTPa) is associated with insulin levels and has been implicated in atherosclerotic disease in both mice and humans. Variation at the PLTP structural locus on chromosome 20 explains some, but not all, heritable variation in PLTPa. In order to detect quantitative trait loci (QTLs) elsewhere in the genome that affect PLTPa, we performed both oligogenic and single QTL linkage analysis on four large families (n = 227 with phenotype, n = 330 with genotype, n = 462 total), ascertained for familial combined hyperlipidemia. We detected evidence of linkage between PLTPa and chromosome 19p (lod = 3.2) for a single family and chromosome 2q (lod = 2.8) for all families. Inclusion of additional marker and exome sequence data in the analysis refined the linkage signal on chromosome 19 and implicated coding variation in LASS4, a gene regulated by leptin that is involved in ceramide synthesis. Association between PLTPa and LASS4 variation was replicated in the other three families (P = 0.02), adjusting for pedigree structure. To our knowledge, this is the first example for which exome data was used in families to identify a complex QTL that is not the structural locus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.