ArticleCellular immunology2011
Evaluation of macrophage plasticity in brown and white adipose tissue.
Article in Cellular immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Immune Cells in Thermogenic Adipose Depots: The Essential but Complex Relationship.Frontiers in endocrinology · 2022Review
- Spontaneous Browning of White Adipose Tissue Improves Angiogenesis and Reduces Macrophage Infiltration After Fat Grafting in Mice.Frontiers in cell and developmental biology · 2022Article
- Uncovering the Role of p38 Family Members in Adipose Tissue Physiology.Frontiers in endocrinology · 2020Review
- Genetics-based manipulation of adipose tissue sympathetic innervation.Physiology & behavior · 2018Review
- Article
- The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications.Mediators of inflammation · 2017Review
- Article
- Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses.Mediators of inflammation · 2017Article
- Establishment and characterization of DB-1: a leptin receptor-deficient murine macrophage cell line.Cytotechnology · 2016Article
- MafB deficiency accelerates the development of obesity in mice.FEBS open bio · 2016Article
- The role of innate immunity in the regulation of brown and beige adipogenesis.Reviews in endocrine & metabolic disorders · 2016Review
- Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications.International journal of endocrinology · 2016Review
- Bone marrow leptin signaling mediates obesity-associated adipose tissue inflammation in male mice.Endocrinology · 2014Article
- Overexpression of IL-10 in C2D macrophages promotes a macrophage phenotypic switch in adipose tissue environments.PloS one · 2014Article
- Macrophages: plastic solutions to environmental heterogeneity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Review
- Lymphocytes in obesity-related adipose tissue inflammation.Diabetologia · 2012Review
- Brown adipose tissue: Recent insights into development, metabolic function and therapeutic potential.Adipocyte · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
There are still questions about whether macrophage differentiation is predetermined or is induced in response to tissue microenvironments. C2D macrophage cells reside early in the macrophage lineage in vitro, but differentiate to a more mature phenotype after adoptive transfer to the peritoneal cavity (PEC-C2D). Since C2D macrophage cells also traffic to adipose tissue after adoptive transfer, we explored the impact of white adipose tissue (WAT), brown adipose tissue (BAT) and in vitro cultured adipocytes on C2D macrophage cells. When PEC-C2D macrophage cells were cultured with preadipocytes the cells stretched out and CD11b and Mac-2 expression was lower compared to PEC-C2D macrophage cells placed in vitro alone. In contrast, PEC-C2D cells co-cultured with adipocytes maintained smaller, round morphology and more cells expressed Mac-2 compared to PEC-C2D co-cultured with preadipocytes. After intraperitoneal injection, C2D macrophage cells migrated into both WAT and BAT. A higher percentage of C2D macrophage cells isolated from WAT (WAT-C2D) expressed Ly-6C (33%), CD11b (11%), Mac-2 (11%) and F4/80 (29%) compared to C2D macrophage cells isolated from BAT (BAT-C2D). Overall, BAT-C2D macrophage cells had reduced expression of many cytokine, chemokine and receptor gene transcripts when compared to in vitro grown C2D macrophages, while WAT-C2D macrophage cells and PEC-C2D up-regulated many of these gene transcripts. These data suggest that the C2D macrophage phenotype can change rapidly and distinct phenotypes are induced by different microenvironments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.