Evidence map›Paper›PMID 21757184›Full record

SynthesisBiological psychiatry2011

The neural basis of drug stimulus processing and craving: an activation likelihood estimation meta-analysis.

Henry W Chase, Simon B Eickhoff, Angela R Laird, Lee Hogarth

Erratum issuedAbstract readComparative StudyMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Biological psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 173 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 17 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 17 syntheses or guidelines pooled it, 320 citations in OpenAlex.

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  4. Neural Underpinnings of Social Stress in Substance Use Disorders.Current topics in behavioral neurosciences · 2022
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  10. Food cue reactivity and craving predict eating and weight gain: a meta-analytic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2016
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113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Henry W ChaseSchool of Psychology, University of Nottingham, University Park, Nottingham, United Kingdom. Electronic address: chaseh@upmc.edu.
Simon B EickhoffInstitute of Neuroscience and Medicine, Research Centre Jülich, Germany; JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany; Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany.
Angela R LairdResearch Imaging Institute, University of Texas Health Science Center, San Antonio, Texas.
Lee HogarthSchool of Psychology, University of Nottingham, University Park, Nottingham, United Kingdom.
University of Nottingham · GBRWTH Aachen University · DEThe University of Texas Health Science Center at San Antonio · US

Funding

Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
Medical Research Council G0701456NIMH NIH HHS R01 MH074457NIMH NIH HHS R01-MH074457-01A1
6 · The paper itself

Abstract

backgroundThe capacity of drug cues to elicit drug-seeking behavior is believed to play a fundamental role in drug dependence; yet the neurofunctional basis of human drug cue-reactivity is not fully understood. We performed a meta-analysis to identify brain regions that are consistently activated by presentation of drug cues. Studies involving treatment-seeking and nontreatment-seeking substance users were contrasted to determine whether there were consistent differences in the neural response to drug cues between these populations. Finally, to assess the neural basis of craving, consistency across studies in brain regions that show correlated activation with craving was assessed.

methodsAppropriate studies, assessing the effect of drug-related cues or manipulations of drug craving in drug-user populations across the whole brain, were obtained via the PubMed database and literature search. Activation likelihood estimation, a method of quantitative meta-analysis that estimates convergence across experiments by modeling the spatial uncertainty of neuroimaging data, was used to identify consistent regions of activation.

resultsCue-related activation was observed in the ventral striatum (across both subgroups), amygdala (in the treatment-seeking subgroup and overall), and orbitofrontal cortex (in the nontreatment-seeking subgroup and overall) but not insula cortex. Although a different pattern of frontal and temporal lobe activation between the subgroups was observed, these differences were not significant. Finally, right amygdala and left middle frontal gyrus activity were positively associated with craving.

conclusionsThese results substantiate the key neural substrates underlying reactivity to drug cues and drug craving.

Indexed as

AlgorithmsBehavior, AddictiveBrainBrain MappingCuesDrug-Seeking BehaviorHumansPatient Acceptance of Health Care

Identifiers

PMID21757184
PMCPMC4827617
OpenAlexW2019447274

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.