ArticleActa biomaterialia2011
Biodegradable composite scaffolds incorporating an intramedullary rod and delivering bone morphogenetic protein-2 for stabilization and bone regeneration in segmental long bone defects.
Article in Acta biomaterialia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 63 citations in OpenAlex.
- Synthetic biodegradable polymer materials in the repair of tumor-associated bone defects.Frontiers in bioengineering and biotechnology · 2023Review
- Study on the Local Anti-Osteoporosis Effect of Polaprezinc-Loaded Antioxidant Electrospun Membrane.International journal of nanomedicine · 2022Article
- Periosteum Mimetic Coating on Structural Bone AllograftsACS biomaterials science & engineering · 2020Article
- Production of Porous Films Based on Biodegradable Polyesters by the Casting Solution Technique Using a Co-Soluble Porogen (Camphor).Polymers · 2020Article
- Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches.Pharmaceutics · 2020Review
- Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview.Journal of orthopaedic translation · 2020Review
- Modification of 3D printed PCL scaffolds by PVAc and HA to enhance cytocompatibility and osteogenesis.RSC advances · 2019Article
- Stem cells, growth factors and scaffolds in craniofacial regenerative medicine.Genes & diseases · 2016Article
- Injectable dual-gelling cell-laden composite hydrogels for bone tissue engineering.Biomaterials · 2016Article
- In vitro and in vivo evaluation of self-mineralization and biocompatibility of injectable, dual-gelling hydrogels for bone tissue engineering.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Novel applications of statins for bone regeneration.National science review · 2015Article
- Estrogen alone or in combination with parathyroid hormone can decrease vertebral MEF2 and sclerostin expression and increase vertebral bone mass in ovariectomized rats.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Fluoride and calcium-phosphate coated sponges of the magnesium alloy AX30 as bone grafts: a comparative study in rabbits.Journal of materials science. Materials in medicine · 2013Article
- Enhancing the bioactivity of Poly(lactic-co-glycolic acid) scaffold with a nano-hydroxyapatite coating for the treatment of segmental bone defect in a rabbit model.International journal of nanomedicine · 2013Article
- Evaluation of bone regeneration using the rat critical size calvarial defect.Nature protocols · 2012Article
- Building bridges: leveraging interdisciplinary collaborations in the development of biomaterials to meet clinical needs.Advanced materials (Deerfield Beach, Fla.) · 2012Review
- Development of a biodegradable bone cement for craniofacial applications.Journal of biomedical materials research. Part A · 2012Article
- Influence of architecture of β-tricalcium phosphate scaffolds on biological performance in repairing segmental bone defects.PloS one · 2012Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
Abstract
In this study, a two-part bone tissue engineering scaffold was investigated. The scaffold consists of a solid poly(propylene fumarate) (PPF) intramedullary rod for mechanical support surrounded by a porous PPF sleeve for osseointegration and delivery of poly(dl-lactic-co-glycolic acid) (PLGA) microspheres with adsorbed recombinant human bone morphogenetic protein-2 (rhBMP-2). Scaffolds were implanted into critical size rat segmental femoral defects with internal fixation for 12 weeks. Bone formation was assessed throughout the study via radiography, and following euthanasia, via microcomputed tomography and histology. Mechanical stabilization was evaluated further via torsional testing. Experimental implant groups included the PPF rod alone and the rod with a porous PPF sleeve containing PLGA microspheres with 0, 2 or 8 μg of rhBMP-2 adsorbed onto their surface. Results showed that presence of the scaffold increased mechanical stabilization of the defect, as evidenced by the increased torsional stiffness of the femurs by the presence of a rod compared to the empty defect. Although the presence of a rod decreased bone formation, the presence of a sleeve combined with a low or high dose of rhBMP-2 increased the torsional stiffness to 2.06 ± 0.63 and 1.68 ± 0.56 N·mm, respectively, from 0.56 ± 0.24 N·mm for the rod alone. The results indicate that, while scaffolds may provide structural support to regenerating tissues and increase their mechanical properties, the presence of scaffolds within defects may hinder overall bone formation if they interfere with cellular processes.
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Registered trials
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