ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2011
Tuberculosis in HIV programmes in lower-income countries: practices and risk factors.
Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Antiretroviral therapy for prevention of tuberculosis in adults with HIV: a systematic review and meta-analysis.PLoS medicine · 2012Pooled it
- Isoniazid plus antiretroviral therapy to prevent tuberculosis: a randomised double-blind, placebo-controlled trial.Lancet (London, England) · 2014Trial
- Isoniazid and rifapentine treatment effectively reduces persistent M. tuberculosis infection in macaque lungs.The Journal of clinical investigation · 2022Article
- Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a Mycobacterium tuberculosis/SIV coinfection model.The Journal of clinical investigation · 2022Article
- Incidence of Tuberculosis During the First Year of Antiretroviral Treatment in West African HIV-Infected Adults.Open forum infectious diseases · 2020Article
- International epidemiology databases to evaluate AIDS (IeDEA) in sub-Saharan Africa, 2012-2019.BMJ open · 2020Article
- Article
- Effectiveness of isoniazid preventative therapy in reducing incidence of active tuberculosis among people living with HIV/AIDS in public health facilities of Addis Ababa, Ethiopia: a historical cohort study.BMC infectious diseases · 2017Article
- Tuberculosis screening outcomes for newly diagnosed persons living with HIV, Nyanza Province, Kenya, 2009.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2016Article
- Article
- Tuberculosis in Pediatric Antiretroviral Therapy Programs in Low- and Middle-Income Countries: Diagnosis and Screening Practices.Journal of the Pediatric Infectious Diseases Society · 2015Article
- Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2014Article
- Predictors of tuberculosis and human immunodeficiency virus co-infection: a case-control study.Epidemiology and health · 2014Article
- Immune recovery after starting ART in HIV-infected patients presenting and not presenting with tuberculosis in South Africa.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Cohort profile: the Themba Lethu Clinical Cohort, Johannesburg, South Africa.International journal of epidemiology · 2013Article
- Tuberculosis and the risk of opportunistic infections and cancers in HIV-infected patients starting ART in Southern Africa.Tropical medicine & international health : TM & IH · 2013Article
- A survey of paediatric HIV programmatic and clinical management practices in Asia and sub-Saharan Africa--the International epidemiologic Databases to Evaluate AIDS (IeDEA).Journal of the International AIDS Society · 2013Article
- Tuberculosis in antiretroviral treatment programs in lower income countries: availability and use of diagnostics and screening.PloS one · 2013Article
- Tuberculosis in HIV-negative and HIV-infected patients in a low-incidence country: clinical characteristics and treatment outcomes.PloS one · 2012Article
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Authors and funding
21 authors at 11 institutions in 10 countries.
Funding
Abstract
backgroundTuberculosis (TB) is a common diagnosis in human immunodeficiency virus (HIV) infected patients on antiretroviral treatment (ART).
objectiveTo describe TB-related practices in ART programmes in lower-income countries and identify risk factors for TB in the first year of ART.
methodsProgramme characteristics were assessed using standardised electronic questionnaire. Patient data from 2003 to 2008 were analysed and incidence rate ratios (IRRs) calculated using Poisson regression models.
resultsFifteen ART programmes in 12 countries in Africa, South America and Asia were included. Chest X-ray, sputum microscopy and culture were available free of charge in respectively 13 (86.7%), 14 (93.3%) and eight (53.3%) programmes. Eight sites (53.3%) used directly observed treatment and five (33.3%) routinely administered isoniazid preventive treatment (IPT). A total of 19 413 patients aged ≥ 16 years contributed 13,227 person-years of follow-up; 1081 new TB events were diagnosed. Risk factors included CD4 cell count (>350 cells/μl vs. <25 cells/μl, adjusted IRR 0.46, 95%CI 0.33-0.64, P < 0.0001), sex (women vs. men, adjusted IRR 0.77, 95%CI 0.68-0.88, P = 0.0001) and use of IPT (IRR 0.24, 95%CI 0.19-0.31, P < 0.0001).
conclusionsDiagnostic capacity and practices vary widely across ART programmes. IPT prevented TB, but was used in few programmes. More efforts are needed to reduce the burden of TB in HIV co-infected patients in lower income countries.
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