ArticleCanadian journal of psychiatry. Revue canadienne de psychiatrie2011
Synaptosomal-associated protein 25 gene polymorphisms and antisocial personality disorder: association with temperament and psychopathy.
Article in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 24 citations in OpenAlex.
- Born this way? A review of neurobiological and environmental evidence for the etiology of psychopathy.Personality neuroscience · 2019Review
- Genome-wide association study of antisocial personality disorder.Translational psychiatry · 2016Article
- Genetic and Neuroimaging Features of Personality Disorders: State of the Art.Neuroscience bulletin · 2016Review
- Antisocial personality disorder: a current review.Current psychiatry reports · 2013Review
- Non-Mendelian etiologic factors in neuropsychiatric illness: pleiotropy, epigenetics, and convergence.The Behavioral and brain sciences · 2012Article
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveThe molecular genetic of personality disorders has been investigated in several studies; however, the association of antisocial behaviours with synaptosomal-associated protein 25 (SNAP25) gene polymorphisms has not. This association is of interest as SNAP25 gene polymorphism has been associated with attention-deficit hyperactivity disorder and personality.
methodsWe compared the distribution of DdeI and MnII polymorphisms in 91 young male offenders and in 38 sex-matched healthy control subjects. We also investigated the association of SNAP25 gene polymorphisms with severity of psychopathy and with temperament traits: novelty seeking, harm avoidance, and reward dependence.
resultsThe MnII T/T and DdeI T/T genotypes were more frequently present in male subjects with antisocial personality disorder (APD) than in sex-matched healthy control subjects. The association was stronger when the frequency of both DdeI and MnII T/T were taken into account. In the APD group, the genotype was not significantly associated with the Psychopathy Checklist-Revised scores, measuring the severity of psychopathy. However, the APD subjects with the MnII T/T genotype had higher novelty seeking scores; whereas, subjects with the DdeI T/T genotype had lower reward dependence scores. Again, the association between genotype and novelty seeking was stronger when both DdeI and MnII genotypes were taken into account.
conclusionDdeI and MnII T/T genotypes may be a risk factor for antisocial behaviours. The association of the SNAP25 DdeI T/T and MnII T/T genotypes with lower reward dependence and higher novelty seeking suggested that SNAP25 genotype might influence other personality disorders, as well.
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