Evidence map›Paper›PMID 21756334›Full record

ArticleBMC bioinformatics2011

Construct and Compare Gene Coexpression Networks with DAPfinder and DAPview.

Jeff Skinner, Yuri Kotliarov, Sudhir Varma, Karina L Mine, Anatoly Yambartsev, Richard Simon, Yentram Huyen, Andrey Morgun

Abstract read
In one paragraph

Article in BMC bioinformatics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jeff SkinnerBioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), National Institute of Allergy and Infectious Disease (NIAID), National Institutes if Health (NIH), Bethesda, Maryland, USA.
Yuri Kotliarov
Sudhir Varma
Karina L Mine
Anatoly Yambartsev
Richard Simon
Yentram Huyen
Andrey Morgun

Funding

The Danger Model 2: how tissues control ImmunityZIAAI000581 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MATZINGER, POLLY C · 2009 to 2025
$8.5M
Danger 1: initiating and stopping immune responsesZIAAI000868 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MATZINGER, POLLY C · 2009 to 2013
$4.1M
Intramural NIH HHS
6 · The paper itself

Abstract

backgroundDAPfinder and DAPview are novel BRB-ArrayTools plug-ins to construct gene coexpression networks and identify significant differences in pairwise gene-gene coexpression between two phenotypes.

resultsEach significant difference in gene-gene association represents a Differentially Associated Pair (DAP). Our tools include several choices of filtering methods, gene-gene association metrics, statistical testing methods and multiple comparison adjustments. Network results are easily displayed in Cytoscape. Analyses of glioma experiments and microarray simulations demonstrate the utility of these tools.

conclusionsDAPfinder is a new friendly-user tool for reconstruction and comparison of biological networks.

Indexed as

Gene Expression Regulation, NeoplasticGene Regulatory NetworksSoftwareGene Expression ProfilingGliomaHumansOligonucleotide Array Sequence Analysis

Identifiers

PMID21756334
PMCPMC3149583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.