Evidence map›Paper›PMID 21755525›Full record

ReviewMass spectrometry reviews

Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses.

Xianlin Han, Kui Yang, Richard W Gross

Abstract readReview
In one paragraph

Review in Mass spectrometry reviews. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 231 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
231citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

231 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. A Novel Compact Multi-Reflecting Time-of-Flight Mass Spectrometer.Journal of the American Society for Mass Spectrometry · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Lipidomic Profiling of Isolated Nuclei from Mice and Cultured Cells.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Mechanism of Obesity-Related Lipotoxicity and Clinical Perspective.Advances in experimental medicine and biology · 2024
    Review

171 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xianlin HanSanford-Burnham Medical Research Institute, Orlando, FL 32827, USA. xhan@sanfordburnham.org
Kui Yang
Richard W Gross

Funding

Regulation of lipid metabolism in diabetic myocardiumP01HL057278 · NHLBI · WASHINGTON UNIVERSITY · PI GROSS, RICHARD W · 1996 to 2012
$21.8M
Shotgun Lipidomics and Alterations in Sphingolipidomes in Alzheimer's DiseasesR01AG031675 · NIA · WASHINGTON UNIVERSITY · PI HAN, XIANLIN · 2007 to 2011
$2.8M
NHLBI NIH HHS P01 HL057278NHLBI NIH HHS P01 HL57278NIA NIH HHS R01 AG031675NIA NIH HHS R01 AG31675
6 · The paper itself

Abstract

Since our last comprehensive review on multi-dimensional mass spectrometry-based shotgun lipidomics (Mass Spectrom. Rev. 24 (2005), 367), many new developments in the field of lipidomics have occurred. These developments include new strategies and refinements for shotgun lipidomic approaches that use direct infusion, including novel fragmentation strategies, identification of multiple new informative dimensions for mass spectrometric interrogation, and the development of new bioinformatic approaches for enhanced identification and quantitation of the individual molecular constituents that comprise each cell's lipidome. Concurrently, advances in liquid chromatography-based platforms and novel strategies for quantitative matrix-assisted laser desorption/ionization mass spectrometry for lipidomic analyses have been developed. Through the synergistic use of this repertoire of new mass spectrometric approaches, the power and scope of lipidomics has been greatly expanded to accelerate progress toward the comprehensive understanding of the pleiotropic roles of lipids in biological systems.

Indexed as

Chromatography, LiquidComputational BiologyHumansLipidsMass SpectrometryMolecular StructureSpectrometry, Mass, Electrospray IonizationSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationLipids

Identifiers

PMID21755525
PMCPMC3259006

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.