ArticleMedical & biological engineering & computing2011
Electrical stimulation for the suppression of pathological tremor.
Article in Medical & biological engineering & computing, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Peripherical Electrical Stimulation for Parkinsonian Tremor: A Systematic Review.Frontiers in aging neuroscience · 2022Pooled it
- Tremor Control Devices for Essential Tremor: A Systematic Literature Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Pooled it
- Ultrasound-Informed State Estimation of Wrist Tremor Dynamics via Koopman Operator for Personalized Sensory Peripheral Nerve Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Spinal excitability following sensory electrical stimulation of the upper limb.Physiological reports · 2025Article
- Ultrasound Imaging Triggered Tremor Suppression With Personalized Afferent Stimulation Frequency.IEEE transactions on bio-medical engineering · 2025Article
- Targeting the fundamentals for tremors: the frequency and amplitude coding in essential tremor.Journal of biomedical science · 2025Review
- Potential of Individual Upper-Limb Muscles to Contribute to Postural Tremor: Simulations From Neural Drive to Joint Rotation.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Shaking Up Essential Tremor: Peripheral Devices and Mechanical Strategies to Reduce Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Review
- Viscous damping of tremor using a wearable robot with an optimized mechanical metamaterial.Wearable technologies · 2024Article
- A portable, programmable, multichannel stimulator with high compliance voltage for noninvasive neural stimulation of motor and sensory nerves in humans.Scientific reports · 2023Article
- Brief Submotor-Threshold Electrical Stimulation Applied Synchronously Over Wrist Flexor and Extensor Muscles does Not Suppress Essential Tremor, Independent of Stimulation Frequency.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Article
- A review of combined neuromodulation and physical therapy interventions for enhanced neurorehabilitation.Frontiers in human neuroscience · 2023Review
- Bilateral transcranial direct current stimulation may be a feasible treatment of Parkinsonian tremor.Frontiers in neuroscience · 2023Article
- Distribution of tremorogenic activity among the major superficial muscles of the upper limb in persons with Essential tremor.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
- Non-invasive electrical stimulation of peripheral nerves for the management of tremor.Journal of the neurological sciences · 2022Review
- Rationale and Evidence for Peripheral Nerve Stimulation for Treating Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2022Review
- Therapeutic Devices for Motor Symptoms in Parkinson's Disease: Current Progress and a Systematic Review of Recent Randomized Controlled Trials.Frontiers in aging neuroscience · 2022Review
- Identifying and modulating distinct tremor states through peripheral nerve stimulation in Parkinsonian rest tremor.Journal of neuroengineering and rehabilitation · 2021Article
- Essential tremor amplitude modulation by median nerve stimulation.Scientific reports · 2021Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathological tremor is manifested as an involuntary oscillation of one or more body parts. Tremor greatly decreases the quality of life and often prevents the patient from performing daily activities. We hypothesized that sensors-driven multichannel electrical stimulation could stabilize affected joints by activating the antagonistic muscles during involuntary activation of agonist muscles and vice versa (out-of-phase stimulation). Here, we present the new system (hardware and software) and the testing of its operation. The hardware consists of a multichannel stimulator and inertial sensors for feedback. The software implements adaptive sensors-driven control for the out-of-phase stimulation. The system was initially applied to healthy persons at the wrist and elbow joints to test the efficiency of the hardware and software solutions. Predefined rhythmic stimulation resulted in tremulous movement, which subjects could not prevent; yet, they were still able to functionally use their hand. The system was then applied to seven patients with Parkinson's disease and essential tremor for minimization of the wrist joint tremor. In six patients, the adaptive out-of-phase stimulation resulted in a significant decrease in the amplitude of tremor (67 ± 13%). In one patient, the stimulation did not result in the expected reduction of tremor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.