ArticleMycopathologia2011
Transcriptomic and proteomic profile of Aspergillus fumigatus on exposure to artemisinin.
Article in Mycopathologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Review
- Artemisinin Targets Transcription Factor PDR1 and ImpairsAntioxidants (Basel, Switzerland) · 2022Article
- Artemisinin relieves myocardial ischemia-reperfusion injuryFrontiers in pharmacology · 2022Article
- Review
- Secondary Metabolites fromMolecules (Basel, Switzerland) · 2021Review
- Comparative analysis of extracellular proteomes reveals putative effectors of the boxwood blight pathogens, Calonectria henricotiae and C. pseudonaviculata.Bioscience reports · 2021Article
- Synergistic Therapies as a Promising Option for the Treatment of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2020Review
- Protective mechanism of artemisinin on rat bone marrow-derived mesenchymal stem cells against apoptosis induced by hydrogen peroxide via activation of c-Raf-Erk1/2-p90Stem cell research & therapy · 2019Article
- Resistance mechanism and proteins inMycology · 2019Review
- Global Analysis of Cell Wall Genes Revealed Putative Virulence Factors in the DermatophyteFrontiers in microbiology · 2019Article
- Potential applications of artemisinins in ocular diseases.International journal of ophthalmology · 2019Review
- Potential of Gallium as an Antifungal Agent.Frontiers in cellular and infection microbiology · 2019Article
- Zinc and Iron Homeostasis: Target-Based Drug Screening as New Route for Antifungal Drug Development.Frontiers in cellular and infection microbiology · 2019Article
- Proteomic and Metabolomic Characteristics of Extremophilic Fungi Under Simulated Mars Conditions.Frontiers in microbiology · 2019Article
- Artemisinins-a Promising New Treatment for Systemic Lupus Erythematosus: a Descriptive Review.Current rheumatology reports · 2018Review
- Peroxides with Anthelmintic, Antiprotozoal, Fungicidal and Antiviral Bioactivity: Properties, Synthesis and Reactions.Molecules (Basel, Switzerland) · 2017Review
- Novel Pharmacological Activity of Artesunate and Artemisinin: Their Potential as Anti-Tubercular Agents.Journal of clinical medicine · 2017Article
- Comparative Ploidy Proteomics of Candida albicans Biofilms Unraveled the Role of the AHP1 Gene in the Biofilm Persistence Against Amphotericin B.Molecular & cellular proteomics : MCP · 2016Article
- Potential ecological roles of artemisinin produced by Artemisia annua L.Journal of chemical ecology · 2014Review
- A proteomic approach to investigating gene cluster expression and secondary metabolite functionality in Aspergillus fumigatus.PloS one · 2014Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Artemisinin, an antimalarial drug, and its derivatives are reported to have antifungal activity against some fungi. We report its antifungal activity against Aspergillus fumigatus (A. fumigatus), a pathogenic filamentous fungus responsible for allergic and invasive aspergillosis in humans, and its synergistic effect in combination with itraconazole (ITC), an available antifungal drug. In order to identify its molecular targets, we further analyzed transcript and proteomic profiles of the fungus on exposure to the artemisinin. In transcriptomic analysis, a total of 745 genes were observed to be modulated on exposure to artemisinin, and some of them were confirmed by real-time polymerase chain reaction analysis. Proteomic profiles of A. fumigatus treated with artemisinin showed modulation of 175 proteins (66 upregulated and 109 downregulated) as compared to the control. Peptide mass fingerprinting led to the identification of 85 proteins-29 upregulated and 56 downregulated, 65 of which were unique proteins. Consistent with earlier reports of molecular mechanisms of artemisinin and that of other antifungal drugs, we believe that oxidative phosphorylation pathway (64 kDa mitochondrial NADH dehydrogenase), cell wall-associated proteins and enzymes (conidial hydrophobin B protein, cell wall phiA protein, extracellular thaumatin domain protein, 1,3-beta-glucanosyltransferase Gel2) and genes involved in ergosterol biosynthesis (ERG6 and coproporphyrinogen III oxidase, HEM13) are potential targets of artemisinin for further investigations.
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