ArticlePloS one2011
Performance of risk-based criteria for targeting acute HIV screening in San Francisco.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Risk-Based Screening Tools to Optimise HIV Testing Services: a Systematic Review.Current HIV/AIDS reports · 2022Pooled it
- Acute and early HIV infection screening among men who have sex with men, a systematic review and meta-analysis.Journal of the International AIDS Society · 2020Pooled it
- A Four-Item Risk Score to Target Acute HIV Infection Testing Among Men Who Have Sex With Men in Indonesia: Development and Validation in the INTERACT Prospective Cohort.Journal of the International AIDS Society · 2026Article
- Performance of a tool to identify different types of self-reported sexual risk among women attending a contraception and sexual health clinic: results of a cross-sectional survey.BMJ sexual & reproductive health · 2021Article
- Detecting Social and Behavioral Determinants of Health with Structured and Free-Text Clinical Data.Applied clinical informatics · 2020Article
- Using Clinical Notes and Natural Language Processing for Automated HIV Risk Assessment.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- False-positive HIV nucleic acid amplification testing during CAR T-cell therapy.Diagnostic microbiology and infectious disease · 2017Article
- Real-world performance of the new US HIV testing algorithm in medical settings.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2017Article
- Screening for acute HIV infection in community-based settings: Cost-effectiveness and impact on transmissions.The Journal of infection · 2016Article
- Costs per Diagnosis of Acute HIV Infection in Community-based Screening Strategies: A Comparative Analysis of Four Screening Algorithms.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Ten Years of Screening and Testing for Acute HIV Infection in North Carolina.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- The Transition From Postexposure Prophylaxis to Preexposure Prophylaxis: An Emerging Opportunity for Biobehavioral HIV Prevention.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Article
- Subsequent HIV infection among men who have sex with men who used non-occupational post-exposure prophylaxis at a Boston community health center: 1997-2013.AIDS patient care and STDs · 2015Article
- How can we better identify early HIV infections?Current opinion in HIV and AIDS · 2015Review
- Prevalence of undiagnosed acute and chronic HIV in a lower-prevalence urban emergency department.American journal of public health · 2014Article
- Targeting screening and social marketing to increase detection of acute HIV infection in men who have sex with men in Vancouver, British Columbia.AIDS (London, England) · 2013Article
- HIV nucleic acid amplification testing versus rapid testing: it is worth the wait. Testing preferences of men who have sex with men.Journal of acquired immune deficiency syndromes (1999) · 2012Article
- HIV testing: the cornerstone of HIV prevention efforts in the USA.Future virology · 2011Article
- Targeting the use of pooled HIV RNA screening to reduce cost in health department STD clinics: New York City, 2009-2011.Public health reports (Washington, D.C. : 1974)Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFederal guidelines now recommend supplemental HIV RNA testing for persons at high risk for acute HIV infection. However, many rapid HIV testing sites do not include HIV RNA or p24 antigen testing due to concerns about cost, the need for results follow-up, and the impact of expanded venipuncture on clinic flow. We developed criteria to identify patients in a municipal STD clinic in San Francisco who are asymptomatic but may still be likely to have acute infection.
methodsData were from patients tested with serial HIV antibody and HIV RNA tests to identify acute HIV infection. BED-CEIA results were used to classify non-acute cases as recent or longstanding. Demographics and self-reported risk behaviors were collected at time of testing. Multivariate models were developed and preliminarily evaluated using predictors associated with recent infection in bivariate analyses as a proxy for acute HIV infection. Multivariate models demonstrating ≥70% sensitivity for recent infection while testing ≤60% of patients in this development dataset were then validated by determining their performance in identifying acute infections.
resultsFrom 2004-2007, 137 of 12,622 testers had recent and 36 had acute infections. A model limiting acute HIV screening to MSM plus any one of a series of other predictors resulted in a sensitivity of 83.3% and only 47.6% of patients requiring testing. A single-factor model testing only patients reporting any receptive anal intercourse resulted in 88.9% sensitivity with only 55.2% of patients requiring testing.
conclusionsIn similar high risk HIV testing sites, acute screening using "supplemental" HIV p24 antigen or RNA tests can be rationally targeted to testers who report particular HIV risk behaviors. By improving the efficiency of acute HIV testing, such criteria could facilitate expanded acute case identification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.