ArticleInterdisciplinary toxicology2011
Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract.
Article in Interdisciplinary toxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 101 citations in OpenAlex.
- Lebanese Medicinal Plants with Ophthalmic Properties.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Potential therapeutic effects of green tea (Heliyon · 2024Review
- Aldose Reductase as a Key Target in the Prevention and Treatment of Diabetic Retinopathy: A Comprehensive Review.Biomedicines · 2024Review
- Antioxidant Nutraceutical Strategies in the Prevention of Oxidative Stress Related Eye Diseases.Nutrients · 2023Review
- Anticataract Effect of the Aqueous Extract of the Flowers ofAdvances in pharmacological and pharmaceutical sciences · 2023Article
- The Aqueous Stem Bark Extract ofScientifica · 2023Article
- Silymarin from Milk Thistle Fruits Counteracts Selected Pathological Changes in the Lenses of Type 1 Diabetic Rats.Nutrients · 2022Article
- Knockdown of miR-423-5p simultaneously upgrades the eNOS and VEGFa pathways in ADSCs and improves erectile function in diabetic rats.Journal of cellular and molecular medicine · 2021Article
- Effects ofAntioxidants (Basel, Switzerland) · 2020Article
- Ethnoveterinary plants of Pakistan: a review.Journal of ethnobiology and ethnomedicine · 2020Review
- Recent Research on the Health Benefits of Blueberries and Their Anthocyanins.Advances in nutrition (Bethesda, Md.) · 2020Review
- Dietary flavonoids inhibit the glycation of lens proteins: implications in the management of diabetic cataract.3 Biotech · 2019Article
- The Action of Polyphenols in Diabetes Mellitus and Alzheimer's Disease: A Common Agent for Overlapping Pathologies.Current neuropharmacology · 2019Article
- Phytochemicals: Target-Based Therapeutic Strategies for Diabetic Retinopathy.Molecules (Basel, Switzerland) · 2018Review
- Interpretation of milk research results.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targetingBioscience reports · 2017Article
- Milk, Fruit and Vegetable, and Total Antioxidant Intakes in Relation to Mortality Rates: Cohort Studies in Women and Men.American journal of epidemiology · 2017Article
- Anticataractogenesis and Antiretinopathy Effects of the Novel Protective Agent Containing the Combined Extract of Mango and Vietnamese Coriander in STZ-Diabetic Rats.Oxidative medicine and cellular longevity · 2017Article
- Grape Polyphenols' Effects in Human Cardiovascular Diseases and Diabetes.Molecules (Basel, Switzerland) · 2017Review
- Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract.BMC complementary and alternative medicine · 2016Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cataract is one of the earliest secondary complications of diabetes mellitus. The lens is a closed system with limited capability to repair or regenerate itself. Current evidence supports the view that cataractogenesis is a multifactorial process. Mechanisms related to glucose toxicity, namely oxidative stress, processes of non-enzymatic glycation and enhanced polyol pathway significantly contribute to the development of eye lens opacity under conditions of diabetes. There is an urgent need for inexpensive, non-surgical approaches to the treatment of cataract. Recently, considerable attention has been devoted to the search for phytochemical therapeutics. Several pharmacological actions of natural flavonoids may operate in the prevention of cataract since flavonoids are capable of affecting multiple mechanisms or etiological factors responsible for the development of diabetic cataract. In the present paper, natural flavonoids are reviewed as potential agents that could reduce the risk of cataract formation via affecting multiple pathways pertinent to eye lens opacification. In addition, the bioavailability of flavonoids for the lens is considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.