ArticleNature2011
Low-energy control of electrical turbulence in the heart.
Article in Nature, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 336 citations in OpenAlex.
- Towards Low Energy Atrial Defibrillation.Sensors (Basel, Switzerland) · 2015Trial
- Computational mapping identifies localized mechanisms for ablation of atrial fibrillation.PloS one · 2012Trial
- An integrated platform for 2-D and 3-D optical and electrical mapping of arrhythmias in Langendorff-perfused rabbit hearts.The Journal of physiology · 2026Article
- Article
- Feedback Control of Coupled Nonlinear Oscillators with Uncertain Parameters.Systems & control letters · 2025Article
- Analysing complex excitation patterns in cardiac tissue using wave event networks.Frontiers in network physiology · 2025Article
- Success rates of simulated multi-pulse defibrillation protocols are sensitive to application timing with individual, protocol-specific optimal timings.Frontiers in network physiology · 2025Article
- Experimental studies of spiral wave teleportation in a light sensitive Belousov-Zhabotinsky system.Chaos (Woodbury, N.Y.) · 2024Article
- Spiking at the edge: Excitability at interfaces in reaction-diffusion systems.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Chaos control in cardiac dynamics: terminating chaotic states with local minima pacing.Frontiers in network physiology · 2024Article
- Dissolution of spiral wave's core using cardiac optogenetics.PLoS computational biology · 2023Article
- In silico optical modulation of spiral wave trajectories in cardiac tissue.Pflugers Archiv : European journal of physiology · 2023Article
- Optogenetic Modulation of Arrhythmia Triggers: Proof-of-Concept from Computational Modeling.Cellular and molecular bioengineering · 2023Article
- A Goodwin Model Modification and Its Interactions in Complex Networks.Entropy (Basel, Switzerland) · 2023Article
- Electrical Stimulation for Low-Energy Termination of Cardiac Arrhythmias: a Review.Cardiovascular drugs and therapy · 2023Review
- Optimising low-energy defibrillation in 2D cardiac tissue with a genetic algorithm.Frontiers in network physiology · 2023Article
- The physics of heart rhythm disorders.Physics reports · 2022Article
- Non-monotonous dose response function of the termination of spiral wave chaos.Scientific reports · 2022Article
- Terminating spiral waves with a single designed stimulus: Teleportation as the mechanism for defibrillation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- During Early VF in Rabbit Hearts, His Bundle Pacing is Less Effective Than Working Myocardial Pacing in Modulating Left Ventricular Activation Rates.Cardiovascular engineering and technology · 2022Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 3 countries.
Funding
Abstract
Controlling the complex spatio-temporal dynamics underlying life-threatening cardiac arrhythmias such as fibrillation is extremely difficult, because of the nonlinear interaction of excitation waves in a heterogeneous anatomical substrate. In the absence of a better strategy, strong, globally resetting electrical shocks remain the only reliable treatment for cardiac fibrillation. Here we establish the relationship between the response of the tissue to an electric field and the spatial distribution of heterogeneities in the scale-free coronary vascular structure. We show that in response to a pulsed electric field, E, these heterogeneities serve as nucleation sites for the generation of intramural electrical waves with a source density ρ(E) and a characteristic time, τ, for tissue depolarization that obeys the power law τ ∝ E(α). These intramural wave sources permit targeting of electrical turbulence near the cores of the vortices of electrical activity that drive complex fibrillatory dynamics. We show in vitro that simultaneous and direct access to multiple vortex cores results in rapid synchronization of cardiac tissue and therefore, efficient termination of fibrillation. Using this control strategy, we demonstrate low-energy termination of fibrillation in vivo. Our results give new insights into the mechanisms and dynamics underlying the control of spatio-temporal chaos in heterogeneous excitable media and provide new research perspectives towards alternative, life-saving low-energy defibrillation techniques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.