ArticleAmerican journal of hypertension2011
Long-chain omega-3 fatty acids and blood pressure.
Article in American journal of hypertension, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00663871 (BioBehavioral Studies of Cardiovascular Disease), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BioBehavioral Studies of Cardiovascular Disease
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Bioactive Compounds and Their Effect on Blood Pressure-A Review.Nutrients · 2020Pooled it
- Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2012Trial
- Nutritional Composition, Health Benefits and Claim Conditions of Fish from Aquaculture: A Narrative Review.Nutrients · 2026Review
- Sex Differences in Fatty Acid Metabolism and Blood Pressure Response to Dietary Salt in Humans.Cardiogenetics · 2023Article
- Hypertension and Dyslipidemia Combined Therapeutic Approaches.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022Review
- Long-chain omega-3 fatty acid serum concentrations across life stages in the USA: an analysis of NHANES 2011-2012.BMJ open · 2021Article
- Antihypertensive activity of oleanolic acid is mediated via downregulation of secretory phospholipase A2 and fatty acid synthase in spontaneously hypertensive rats.International journal of molecular medicine · 2020Article
- Disrupted Lipid Raft Shuttling of FcεRI by n-3 Polyunsaturated Fatty Acid Is Associated With Ligation of G Protein-Coupled Receptor 120 (GPR120) in Human Mast Cell Line LAD2.Frontiers in nutrition · 2020Article
- Long-Chain Polyunsaturated Fatty Acids Are Associated with Blood Pressure and Hypertension over 10-Years in Black South African Adults Undergoing Nutritional Transition.Foods (Basel, Switzerland) · 2019Article
- Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues.International journal of molecular sciences · 2019Review
- Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults.Journal of hypertension · 2018Article
- Mechanisms of BK Channel Activation by Docosahexaenoic Acid in Rat Coronary Arterial Smooth Muscle Cells.Frontiers in pharmacology · 2018Article
- Nutritional Supplements for the Treatment of Hypertension: A Practical Guide for Clinicians.Current cardiology reports · 2016Review
- Role of Dietary Components in Modulating Hypertension.Journal of clinical & experimental cardiology · 2016Article
- Exploratory serum fatty acid patterns associated with blood pressure in community-dwelling middle-aged and elderly Chinese.Lipids in health and disease · 2016Article
- In-Depth Study of the Interaction, Sensitivity, and Gating Modulation by PUFAs on KFrontiers in physiology · 2016Review
- An omega-3 epoxide of docosahexaenoic acid lowers blood pressure in angiotensin-II-dependent hypertension.Journal of cardiovascular pharmacology · 2014Article
- The role of nutrition and nutraceutical supplements in the treatment of hypertension.World journal of cardiology · 2014Review
- Nutrition and nutraceutical supplements for the treatment of hypertension: part II.Journal of clinical hypertension (Greenwich, Conn.) · 2013Review
- A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid.The Journal of general physiology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundHigh dose fish oil supplementation reduces blood pressure (BP) in hypertensive patients. The current study examines how modest variations in omega-3 fatty acid intake may affect BP in a healthy community sample.
methodsStudy participants included 265 Pittsburgh-area adults 30-54 years of age (11% black, 51% female) not taking omega-3 fatty acid supplements or antihypertensive medications. Standardized assessments of clinic and 24-h ambulatory BP, and pulse rate were obtained. Docosahexanenoic acid (DHA) and eicosapentaenoic acid (EPA) in fasting serum phospholipids were measured by capillary gas chromatography. Regression analyses controlled for age, gender, race, body mass index (BMI), self-reported sodium intake, and physical activity.
resultsParticipants included 181(68%) normotensives, 66 (25%) prehypertensives, and 18 (7%) persons with untreated hypertension. DHA was inversely associated with clinic diastolic (β = -0.121, P = 0.03), awake ambulatory diastolic BP (β = -0.164, P = 0.004), and 24-h diastolic BP (β = -0.135, P = 0.02). A two standard deviation greater DHA was associated with 2.1 mm Hg lower clinic and 2.3 mm Hg lower awake ambulatory diastolic BP. In addition, DHA was inversely associated with pulse rate measured at rest in the clinic. EPA was related to clinic pulse rate but not clinic or ambulatory BP.
conclusionIn this sample of American adults not on antihypertensive medications, a modest, inverse association was found between DHA exposure and both clinic and ambulatory diastolic BP. Therefore, increasing DHA consumption through diet modification rather than large dose supplementation represents a candidate strategy for future studies of hypertension prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.