ArticleJournal of molecular evolution1990
Chemical esterification of 5'-AMP occurs predominantly at the 2' position.
Article in Journal of molecular evolution, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Catalytic roles of the AMP at the 3' end of tRNAs.Molecular and cellular biochemistry · 1994Article
- Preferential hydrophobic interactions are responsible for a preference of D-amino acids in the aminoacylation of 5'-AMP with hydrophobic amino acids.Experientia · 1992Article
- Experimental studies on the origin of the genetic code and the process of protein synthesis: a review update.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1992Review
- Mixed anhydrides (phosphoric-carboxyl) are also formed in the esterification of 5'-AMP with N-acetylaminoacyl imidazolides: implications regarding the origin of protein synthesis.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1992Article
- Ribonucleic acids may be catalysts for the preferential synthesis of L-amino acid peptides: a minireview.Journal of molecular evolution · 1990Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe experiments here which show that chemical esterification of 5'-adenylic acid (5'-AMP) with N-acetyl D- or L-phenylalanine (Ac-D- or Ac-L-Phe) imidazolide occurs principally, if not exclusively, at the 2' position. Furthermore, in experiments with the formation of the 2'-3' diester with butyric acid and N-acetyl glycine (Ac-Gly), we found the second esterification was also predominantly at the 2' position. This means that mixed diesters can be predictably prepared with the positions of the substituents known. The results are consistent with a model for the preferential catalytic synthesis of L-based peptides via a 2'-3' diester intermediate of purine monoribonucleotides.
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Registered trials
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