ArticlePhysics in medicine and biology2011
A photo-multiplier tube-based hybrid MRI and frequency domain fluorescence tomography system for small animal imaging.
Article in Physics in medicine and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Development of a theranostic preclinical fluorescence molecular tomography/cone beam CT-guided irradiator platform.Biomedical optics express · 2022Article
- Resolving tissue chromophore concentration at MRI resolution using multi-wavelength photo-magnetic imaging.Biomedical optics express · 2020Article
- Multimodal Molecular Imaging: Current Status and Future Directions.Contrast media & molecular imaging · 2018Review
- A Sparsity-Constrained Preconditioned Kaczmarz Reconstruction Method for Fluorescence Molecular Tomography.BioMed research international · 2016Article
- Simulation-based evaluation of the resolution and quantitative accuracy of temperature-modulated fluorescence tomography.Applied optics · 2015Article
- Hybrid FMT-MRI applied to in vivo atherosclerosis imaging.Biomedical optics express · 2014Article
- A True Multi-modality Approach for High Resolution Optical Imaging: Photo-Magnetic Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2014Article
- Photo-magnetic imaging: resolving optical contrast at MRI resolution.Physics in medicine and biology · 2013Article
- Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- In vivo validation of quantitative frequency domain fluorescence tomography.Journal of biomedical optics · 2012Article
- Parallel multigrid solver of radiative transfer equation for photon transport via graphics processing unit.Journal of biomedical optics · 2012Article
- Computed tomography-guided time-domain diffuse fluorescence tomography in small animals for localization of cancer biomarkers.Journal of visualized experiments : JoVE · 2012Article
- Temperature-modulated fluorescence tomography based on both concentration and lifetime contrast.Journal of biomedical optics · 2012Article
- A review of indocyanine green fluorescent imaging in surgery.International journal of biomedical imaging · 2012Article
- Imaging workflow and calibration for CT-guided time-domain fluorescence tomography.Biomedical optics express · 2011Article
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Authors and funding
6 authors.
Funding
Abstract
Fluorescence tomography (FT) is a promising molecular imaging technique that can spatially resolve both fluorophore concentration and lifetime parameters. However, recovered fluorophore parameters highly depend on the size and depth of the object due to the ill-posedness of the FT inverse problem. Structural a priori information from another high spatial resolution imaging modality has been demonstrated to significantly improve FT reconstruction accuracy. In this study, we have constructed a combined magnetic resonance imaging (MRI) and FT system for small animal imaging. A photo-multiplier tube is used as the detector to acquire frequency domain FT measurements. This is the first MR-compatible time-resolved FT system that can reconstruct both fluorescence concentration and lifetime maps simultaneously. The performance of the hybrid system is evaluated with phantom studies. Two different fluorophores, indocyanine green and 3-3' diethylthiatricarbocyanine iodide, which have similar excitation and emission spectra but different lifetimes, are utilized. The fluorescence concentration and lifetime maps are both reconstructed with and without the structural a priori information obtained from MRI for comparison. We show that the hybrid system can accurately recover both fluorescence intensity and lifetime within 10% error for two 4.2 mm-diameter cylindrical objects embedded in a 38 mm-diameter cylindrical phantom when MRI structural a priori information is utilized.
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